Meat, Fish, Poultry, and Egg Intake at Diagnosis and Risk of Prostate Cancer Progression
Wilson KM, Mucci LA, Drake BF, Preston MA, Stampfer MJ, Giovannucci E, Kibel AS
Cancer prevention research (Philadelphia, Pa.) · 15 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Food frequency questionnaire
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2016-09-21 · Cancer Prev Res (Phila) · vol. 9 · issue 12 · pp. 933–941
- Publisher
- American Association for Cancer Research
- Cited
- 24 citations · more than 87% of similar papers · 1.8× the field average
- References
- 34 works
- Access
- Open access (repository copy) · CC-BY
- Research areas
- Nutritional Studies and Diet · Consumer Attitudes and Food Labeling · Fatty Acid Research and Health
- Keywords
- Red meat, Prostate cancer, Medicine, Quartile, Cancer, Confidence interval, Internal medicine, Prospective cohort study, Lower risk, Pathology
- MeSH
- animals, poultry, fishes, humans, prostatic neoplasms, neoplasm recurrence, local, disease progression, neoplasm staging, prostatectomy, diet, logistic models, risk factors, cohort studies, prospective studies, eating, eggs, middle aged, male, neoplasm grading, surveys and questionnaires, red meat
7 authors
From US
- Kathryn M. Wilson · correspondingBrigham and Women's Hospital; Harvard University
- Lorelei Ann MucciBrigham and Women's Hospital; Harvard University
- Bettina F. DrakeWashington University in St. Louis
- Mark A. PrestonBrigham and Women's Hospital
- Meir J. StampferBrigham and Women's Hospital; Harvard University
- Edward L. GiovannucciBrigham and Women's Hospital; Harvard University
Abstract
Little information exists on diet and prostate cancer progression. We examined the association between intakes of total red meat, processed and unprocessed red meat, poultry, fish, and eggs and prostate cancer recurrence. We conducted a prospective study of 971 men treated with radical prostatectomy for prostate cancer between 2003 and 2010. Men completed a food frequency questionnaire at diagnosis. We used logistic regression to study the association between diet and high-grade or advanced-stage disease. We used Cox models to study the risk of progression [N = 94 events, mainly prostate-specific antigen (PSA) recurrence]. Total red meat intake was marginally associated with risk of high-grade disease [Gleason ≥ 4+3; adjusted OR top vs. bottom quartile: 1.66; 95% confidence interval (CI), 0.93-2.97; Ptrend = 0.05], as was very high intake of eggs (OR top decile vs. bottom quartile: 1.98; 95% CI, 1.08-3.63, Ptrend = 0.08). Well-done red meat was associated with advanced disease (≥pT3; OR top vs. bottom quartile: 1.74, 95% CI, 1.05-2.90; Ptrend = 0.01). Intakes of red meat, fish, and eggs were not associated with progression. Very high poultry intake was inversely associated with progression (HR top decile vs. bottom quartile: 0.19; 95% CI, 0.06-0.63; Ptrend = 0.02). Substituting 30 g/d of poultry or fish for total or unprocessed red meat was associated with significantly lower risk of recurrence. Lower intakes of red meat and well-done red meat and higher intakes of poultry and fish are associated with lower risk of high grade and advanced prostate cancer and reduced recurrence risk, independent of stage and grade. Cancer Prev Res; 9(12); 933-41. ©2016 AACR.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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