The seasonal importance of serum 25-hydroxyvitamin D for bone mineral density in older women
Michaëlsson K, Wolk A, Byberg L, Mitchell A, Mallmin H, Melhus H
Journal of internal medicine · 40 citations
How it was studied
- Design
- Cohort study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- Forskningsrådet för Arbetsliv och Socialvetenskap
- Government
- Vetenskapsrådet
Based on 2 listed funder(s).
Publication
- Published
- 2016-09-25 · J Intern Med · vol. 281 · issue 2 · pp. 167–178
- Publisher
- Wiley
- Cited
- 46 citations · more than 96% of similar papers · 4.8× the field average
- Impact
- Top 10% most cited in its field
- References
- 46 works
- Access
- Open access (hybrid journal) · CC-BY-NC-ND
- Research areas
- Vitamin D Research Studies · Climate Change and Health Impacts · Nutritional Studies and Diet
- Keywords
- Medicine, Bone mineral, Vitamin D and neurology, Osteoporosis, Confidence interval, Internal medicine, Cohort, Population, Endocrinology, Cohort study
- MeSH
- humans, osteoporosis, postmenopausal, calcium, dietary, vitamin d, risk factors, seasons, bone density, dietary supplements, aged, aged, 80 and over, middle aged, sweden, female
6 authors
From SE
- Karl Michaëlsson · correspondingUppsala University
- Alicja WolkKarolinska Institutet
- Liisa BybergUppsala University
- Adam J. MitchellUppsala University
- H. MallminUppsala University
- Håkan MelhusUppsala University
Abstract
Background
The impact of season when determining a serum 25-hydroxyvitamin D (S-25OHD) cut-off level for optimal bone health is unknown.
Objective
To investigate the relative importance of S-25OHD for bone mineral density (BMD) by season.
Methods
A subcohort of 5002 Swedish women (mean age 68 years), randomly selected from a large population-based longitudinal cohort study with repeat dietary and lifestyle information, was enrolled during 2003-2009 for a clinical examination, which included dual-energy X-ray absorptiometry and collection of fasting blood samples. Categories of vitamin D status were determined by S-25OHD (measured by HPLC-MS/MS).
Results
In samples collected during summer, we found a gradual increase in BMD of the total hip up to a S-25OHD level of 40 nmol L-1 (6% of the cohort). In women with S-25OHD concentrations below 30 nmol L-1 during summer, adjusted BMD was 11% lower [95% confidence interval (CI) 3-19] and in those with S-25OHD levels of 30-40 nmol L-1 BMD was 6% lower (95% CI 1-11), compared with women with S-25OHD levels above 80 nmol L-1 . Low S-25OHD concentrations during summer (-1 ) were also associated with higher adjusted relative risk of osteoporosis (4.9; 95% CI 2.9-8.4) compared with concentrations above 80 nmol L-1 . By contrast, no differences in mean BMD values between categories of S-25OHD were found during winter.
Conclusions
Summer concentrations of S-25OHD appear to be the most useful to predict BMD, whereas winter levels have limited value. To determine a S-25OHD cut-off level for vitamin D deficiency, it may be necessary to take into account the season of blood collection.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC-ND).
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