Dietary nitrate supplementation attenuates the reduction in exercise tolerance following blood donation
McDonagh ST, Vanhatalo A, Fulford J, Wylie LJ, Bailey SJ, Jones AM
American journal of physiology. Heart and circulatory physiology · 12 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Not stated
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2016-09-30 · Am J Physiol Heart Circ Physiol · vol. 311 · issue 6 · pp. H1520–H1529
- Publisher
- American Physical Society
- Cited
- 12 citations · more than 76% of similar papers · 0.9× the field average
- References
- 71 works
- Access
- Free to read
- Research areas
- Biochemical effects in animals · Nitric Oxide and Endothelin Effects · Cardiovascular and exercise physiology
- Keywords
- Reduction (mathematics), Medicine, Blood donor, Donation, Nitrate, Internal medicine, Chemistry, Immunology
- MeSH
- humans, beta vulgaris, nitrates, hemoglobins, exercise test, hematocrit, double-blind method, oxygen consumption, exercise tolerance, dietary supplements, adult, blood donors, female, male, young adult, healthy volunteers, fruit and vegetable juices
6 authors
From GB
- Sinéad T. J. McDonaghUniversity of Exeter
- Anni VanhataloUniversity of Exeter
- Jonathan FulfordUniversity of Exeter
- Lee J. WylieUniversity of Exeter
- Stephen J. BaileyUniversity of Exeter
- ANDREW MARK JONES · correspondingUniversity of Exeter
Abstract
We tested the hypothesis that dietary nitrate (NO3-)-rich beetroot juice (BR) supplementation could partially offset deteriorations in O2 transport and utilization and exercise tolerance after blood donation. Twenty-two healthy volunteers performed moderate-intensity and ramp incremental cycle exercise tests prior to and following withdrawal of ∼450 ml of whole blood. Before donation, all subjects consumed seven 70-ml shots of NO3--depleted BR [placebo (PL)] in the 48 h preceding the exercise tests. During the 48 h after blood donation, subjects consumed seven shots of BR (each containing 6.2 mmol of NO3-, n = 11) or PL (n = 11) before repeating the exercise tests. Hemoglobin concentration and hematocrit were reduced by ∼8-9% following blood donation (P 2 uptake during moderate-intensity exercise was ∼4% lower after than before donation in the BR group (P 3- supplementation reduced the O2 cost of moderate-intensity exercise and attenuated the decline in ramp incremental exercise performance following blood donation. These results have implications for improving functional capacity following blood loss.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
Community trust
Loading…
How much do you trust this study's findings?
Comments
Sign in to rate, comment on or flag this study.Sign inSomething wrong here?
Flag this study if its information, labels or funding look wrong. An editor reviews every flag.
Sign in to rate, comment on or flag this study.Sign inEducational information about published research. Not medical advice, and not a recommendation to start or stop anything.