Creatine metabolism: detection of creatine and guanidinoacetate in saliva of healthy subjects
Martínez LD, Bezard M, Brunotto M, Dodelson de Kremer R
Acta odontologica latinoamericana : AOL · 6 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cross-sectional study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2016-04-01 · Acta Odontol Latinoam · vol. 29 · issue 1 · pp. 49–53
- Publisher
- National Institutes of Health
- Cited
- 10 citations · more than 63% of similar papers · 0.3× the field average
- References
- 0 works
- Access
- Open access (repository copy) · OTHER-OA
- Research areas
- Muscle metabolism and nutrition · Cancer, Hypoxia, and Metabolism
- Keywords
- Saliva, Creatine, Chemistry, Biochemistry
- MeSH
- saliva, humans, creatine, glycine, reference values, adolescent, adult, middle aged, child, child, preschool, female, male, young adult
4 authors
From AR, US
- Lidia Dora MartínezUniversidad Nacional de Córdoba; Cordoba University
- Miriam Bezard
- Mabel Noemí BrunottoUniversidad Nacional de Córdoba; Cordoba University
- Raquel Dodelson de Kremer
Abstract
Creatine (Cr) plays an important role in storage and transmission of phosphate-bound energy. Cerebral creatine deficiency syndromes comprise three inherited defects in Cr biosynthesis and transport. The aim of this study was to investigate whether Cr and Guanidinoacetate (GAA) can be detected in saliva of healthy subjects and to establish the relationship between salivary and plasma levels of these molecules. An adapted gas chromatography (GC) method is described for the quantification of Cr and GAA biomarkers in saliva. Reference values were established for GAA and Cr in saliva. These values were age dependent (p= 0.001). No difference between genders was observed. We detected a difference between GAA and Cr concentrations in saliva and in plasma. The GC method for simultaneous determination of GAA and Cr in human saliva is fast, reliable, sensitive, non-invasive and precise to use as a biochemical approach in early detection of cerebral creatine deficiency syndromes.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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