The relationship between 25-hydroxyvitamin D concentration in early pregnancy and pregnancy outcomes in a large, prospective cohort
Boyle VT, Thorstensen EB, Mourath D, Jones MB, McCowan LM, Kenny LC, Baker PN
The British journal of nutrition · 58 citations
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Independent funding
- Government
- Tertiary Education Commission
- Government
- New Zealand Government
- University or hospital
- University of Auckland
Based on 3 listed funder(s).
Publication
- Published
- 2016-10-18 · Br J Nutr · vol. 116 · issue 8 · pp. 1409–1415
- Publisher
- Cambridge University Press
- Cited
- 83 citations · more than 98% of similar papers · 9.0× the field average
- Impact
- Top 10% most cited in its field
- References
- 39 works
- Access
- Free to read
- Research areas
- Gestational Diabetes Research and Management · Pregnancy and preeclampsia studies · Vitamin D Research Studies
- Keywords
- Vitamin D and neurology, Pregnancy, Medicine, Obstetrics, vitamin D deficiency, Prospective cohort study, Gestation, Cohort study, Gestational diabetes, Small for gestational age, Eclampsia, Population, Cohort, Gestational age, Generation R, Pediatrics, Internal medicine, Environmental health
- MeSH
- humans, pregnancy complications, diabetes, gestational, fetal growth retardation, pre-eclampsia, premature birth, vitamin d deficiency, calcifediol, 25-hydroxyvitamin d 2, pregnancy outcome, severity of illness index, incidence, prevalence, risk, cohort studies, prospective studies, nutritional status, pregnancy, pregnancy trimester, second, new zealand, female, maternal nutritional physiological phenomena, biomarkers
7 authors
From NZ, SE, IE, GB
- Veronica T. Boyle · correspondingUniversity of Auckland
- Eric B. ThorstensenUniversity of Auckland
- David MourathLinköping University
- Beatrix JonesMassey University
- Lesley M. E. McCowanUniversity of Auckland
- Louise C. KennyUniversity College Cork
Abstract
Vitamin D insufficiency and deficiency have been associated with an increased risk of adverse pregnancy outcomes. Controversy remains as findings have been inconsistent between disparate populations. The aim of this study was to investigate the relationship between vitamin D status and pregnancy outcomes in a large, prospective pregnancy cohort. 25-Hydroxyvitamin D concentration was analysed in serum samples collected at 15 weeks of gestation from 1710 New Zealand women participating in a large, observational study. Associations between vitamin D status and pre-eclampsia, preterm birth, small for gestational age (SGA) and gestational diabetes were investigated. The mean 25-hydroxyvitamin D concentration was 72·9 nmol/l. In all, 23 % had 25-hydroxyvitamin D concentrations 75 nmol/l (OR 2·3; 95 % CI 1·1, 5·1). However, this effect was not significant when adjustments were made for BMI and ethnicity (OR 1·8; 95 % CI 0·8, 4·2). 25-Hydroxyvitamin D concentration at 15 weeks was not associated with development of pre-eclampsia, spontaneous preterm birth or SGA infants. Pregnancy complications were low in this largely vitamin D-replete population.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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