Oral magnesium supplementation improves endothelial function and attenuates subclinical atherosclerosis in thiazide-treated hypertensive women
Cunha AR, D'El-Rei J, Medeiros F, Umbelino B, Oigman W, Touyz RM, Neves MF
Journal of hypertension · 50 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2016-10-19 · J Hypertens · vol. 35 · issue 1 · pp. 89–97
- Publisher
- Lippincott Williams & Wilkins
- Cited
- 77 citations · more than 94% of similar papers · 4.0× the field average
- Impact
- Top 10% most cited in its field
- References
- 68 works
- Access
- Paywalled
- Research areas
- Magnesium in Health and Disease · Parathyroid Disorders and Treatments · Cardiovascular Health and Disease Prevention
- Keywords
- Medicine, Pulse wave velocity, Blood pressure, Internal medicine, Thiazide, Arterial stiffness, Placebo, Magnesium, Intima-media thickness, Brachial artery, Hydrochlorothiazide, Hemodynamics, Ambulatory blood pressure, Endocrinology, Cardiology, Carotid arteries, Pathology
- MeSH
- humans, hypertension, magnesium, administration, oral, blood pressure, adult, aged, middle aged, female, carotid intima-media thickness, pulse wave analysis
7 authors
From GB, BR
- Ana Rosa CunhaBritish Heart Foundation; University of Glasgow
- Jenifer d’El-ReiBritish Heart Foundation; University of Glasgow
- Fernanda MedeirosBritish Heart Foundation; University of Glasgow
- Bianca UmbelinoBritish Heart Foundation; University of Glasgow
- Wille OigmanBritish Heart Foundation; University of Glasgow
- Rhian M. TouyzBritish Heart Foundation; University of Glasgow
Abstract
Background
Epidemiological studies demonstrate an inverse association between serum magnesium and incidence of cardiovascular disease. Diuretics commonly cause hypomagneseamia.
Method
We evaluated effects of magnesium supplementation on blood pressure (BP) and vascular function in thiazide-treated hypertensive women in a randomized, double-blind, clinical trial. Hypertensive women (40-65 years) on hydrochlorothiazide and mean 24-h BP at least 130/80 mmHg were divided into placebo and supplementation (magnesium chelate 600 mg/day) groups. Patients were evaluated for nutritional and biochemical parameters, office and ambulatory blood pressure monitoring, brachial flow-mediated dilatation (FMD), peripheral arterial tonometry, assessment of carotid intima-media thickness, central hemodynamic parameters and pulse wave velocity at inclusion and after 6-month follow-up.
Results
The magnesium group had a significant reduction in SBP (144 ± 17 vs. 134 ± 14 mmHg, P = 0.036) and DBP (88 ± 9 vs. 81 ± 8 mmHg, P = 0.005) at 6 months, without effect on plasma glucose, lipids, or arterial stiffness parameters. The placebo group showed a significant increase in carotid intima-media thickness (0.78 ± 0.13 vs. 0.89 ± 0.14 mm, P = 0.033) without change in the magnesium group (0.79 ± 0.16 vs. 0.79 ± 0.19 mm, P = 0.716) after 6 months. The magnesium group demonstrated a significant increase in variation of FMD vs. the placebo group (+3.7 ± 2.1 vs. 2.4 ± 1.2%, P = 0.015). There was a significant correlation between the intracellular magnesium variation and FMD (r = 0.44, P = 0.011).
Conclusion
Magnesium supplementation was associated with better BP control, improved endothelial function and amelioration of subclinical atherosclerosis in these thiazide-treated hypertensive women.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
Community trust
Loading…
How much do you trust this study's findings?
Comments
Sign in to rate, comment on or flag this study.Sign inSomething wrong here?
Flag this study if its information, labels or funding look wrong. An editor reviews every flag.
Sign in to rate, comment on or flag this study.Sign inEducational information about published research. Not medical advice, and not a recommendation to start or stop anything.