Autonomic thermoregulatory dysfunction in neurofibromatosis type 1
Madeira LG, Passos RL, Souza JF, Rezende NA, Rodrigues LO
Arquivos de neuro-psiquiatria · 3 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Case-control study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2016-10-01 · Arq Neuropsiquiatr · vol. 74 · issue 10 · pp. 796–802
- Publisher
- Thieme Medical Publishers (Germany)
- Cited
- 7 citations · more than 60% of similar papers · 0.2× the field average
- References
- 30 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Sympathectomy and Hyperhidrosis Treatments · Neurofibromatosis and Schwannoma Cases · Urinary Bladder and Prostate Research
- Keywords
- Neurofibromatosis, Medicine, Psychology, Pathology
- MeSH
- sweat, skin, humans, neurofibromatosis 1, analysis of variance, case-control studies, age factors, sex factors, body temperature regulation, sweating, time factors, reference values, adolescent, adult, middle aged, female, male, primary dysautonomias, young adult
5 authors
From BR
- Luciana Gonçalves MadeiraUniversidade Federal de Minas Gerais
- Renata L. Freitas PassosUniversidade Federal de Minas Gerais
- Juliana Ferreira de SouzaUniversidade Federal de Minas Gerais; Hospital das Clínicas da Universidade Federal de Minas Gerais
- Nilton Alves de RezendeUniversidade Federal de Minas Gerais; Hospital das Clínicas da Universidade Federal de Minas Gerais
- Luiz Oswaldo Carneiro RodriguesUniversidade Federal de Minas Gerais; Hospital das Clínicas da Universidade Federal de Minas Gerais
Abstract
Objective
Neurofibromatosis type 1 (NF1) causes neural and cutaneous disorders and reduced exercise capacity. Exercise/heat exposure increasing internal temperature must be compensated by eccrine sweat function and warmed skin vasodilation. We suspected NF1 could adversely affect eccrine sweat function and/or vascular thermoregulatory responses (VTR).
Methods
The eccrine sweat function and VTR of 25 NF1 volunteers (14 males, 11 females; 16-57 years old) were compared with 23 non-NF1 controls matched by sex, age, height and weight (CG). Sweating was induced by 1) pilocarpine 1% iontophoresis (PILO); and 2) by passive heating (HEAT) via the lower third of the legs being immersed in 42°C water for one hour. Previously established eccrine sweat function and VTR protocols were used.
Results
The NF1 group showed: a) lower sweat rate than the CG group during PILO; b) a smaller diastolic pressure decrease; and c) higher tympanic temperatures than controls during HEAT (p < 0.05).
Conclusion
Reduced sweating and vascular thermoregulatory responses suggest autonomic dysfunction in NF1 individuals.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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