Dietary Magnesium and Kidney Function Decline: The Healthy Aging in Neighborhoods of Diversity across the Life Span Study
Rebholz CM, Tin A, Liu Y, Kuczmarski MF, Evans MK, Zonderman AB, Crews DC
American journal of nephrology · 39 citations
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- U.S. Department of Agriculture
- Government
- National Institute of Diabetes and Digestive and Kidney Diseases
- Government
- NIDDK NIH HHS
- Grants
- National Institute of Diabetes and Digestive and Kidney Diseases (K01-DK-107782); National Institute of Diabetes and Digestive and Kidney Diseases (K23DK097184)
Based on 3 listed funder(s).
Publication
- Published
- 2016-01-01 · Am J Nephrol · vol. 44 · issue 5 · pp. 381–387
- Publisher
- Karger Publishers
- Cited
- 53 citations · more than 92% of similar papers · 3.5× the field average
- Impact
- Top 10% most cited in its field
- References
- 51 works
- Access
- Open access (repository copy)
- Research areas
- Magnesium in Health and Disease · Parathyroid Disorders and Treatments · Potassium and Related Disorders
- Keywords
- Medicine, Renal function, Kidney disease, Internal medicine, Magnesium, Endocrinology, Gerontology, Physiology, Chemistry
- MeSH
- kidney, humans, magnesium deficiency, magnesium, glomerular filtration rate, diet surveys, prospective studies, aging, adult, middle aged, female, male, renal insufficiency
7 authors
From US, CA
- Casey M. RebholzJohns Hopkins University
- Adrienne TinJohns Hopkins University
- Yang LiuJohns Hopkins University; Johns Hopkins Medicine
- Marie Fanelli KuczmarskiUniversity of Delaware
- Michele K. EvansNational Institutes of Health; Institute of Aging
- Alan B. ZondermanNational Institutes of Health; Institute of Aging
Abstract
Background
Prior studies suggest that certain aspects of the diet related to magnesium intake, such as dietary acid load, protein intake and dietary patterns rich in fruits and vegetables, may impact kidney disease risk. We hypothesized that lower dietary magnesium intake would be prospectively associated with more rapid kidney function decline.
Methods
Among participants in the Healthy Aging in Neighborhoods of Diversity across the Life Span study with estimated glomerular filtration rate (eGFR) ≥60 ml/min/1.73 m2 at baseline (2004-2009), dietary magnesium intake was calculated from two 24-hour dietary recalls. Rapid decline was defined as ≥3% eGFR decline per year.
Results
Median (25th-75th percentile) dietary magnesium intake was 116 (96-356) mg/1,000 kcal. Among 1,252 participants, those with lower dietary magnesium intake were younger, and were more likely to be African-American men. A total of 177 participants (14.1%) experienced rapid eGFR decline over a median follow-up of 5 years. Lower dietary magnesium intake was significantly associated with a greater odds of rapid eGFR decline (OR for tertile 1 vs. 3: 2.02, 95% CI 1.05-3.86, p value for trend across tertiles = 0.02) in analyses adjusted for sociodemographics (age, sex, race, education level, health insurance status, poverty status), kidney disease risk factors (smoking status, diabetes, hemoglobin A1c, hypertension, body mass index), baseline eGFR and dietary factors (total energy intake; diet quality; dietary intake of fiber, sodium, calcium, potassium and phosphorus).
Conclusions
In this urban population, lower dietary magnesium intake was independently associated with greater odds of rapid kidney function decline.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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