Docosahexaenoic acid liposomes for targeting chronic inflammatory diseases and cancer: an in vitro assessment
Alaarg A, Jordan NY, Verhoef JJ, Metselaar JM, Storm G, Kok RJ
International journal of nanomedicine · 37 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- In vitro/mechanistic study (classified by our AI screen)
- Studied in
- People, plus animal or lab work
- Main outcome
- Mechanisms only
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2016-10-01 · Int J Nanomedicine · vol. Volume 11 · pp. 5027–5040
- Publisher
- Dove Medical Press
- Cited
- 59 citations · more than 95% of similar papers · 4.7× the field average
- Impact
- Top 10% most cited in its field
- References
- 48 works
- Access
- Open access (journal) · CC-BY-NC
- Research areas
- Fatty Acid Research and Health · Cholesterol and Lipid Metabolism · Eicosanoids and Hypertension Pharmacology
- Keywords
- Docosahexaenoic acid, Fish oil, Proinflammatory cytokine, Polyunsaturated fatty acid, Inflammation, Liposome, Immune system, Eicosapentaenoic acid, Cancer, Cancer cell, Cancer research, Pharmacology, Reactive oxygen species, Chemistry, Immunology, Medicine, Biology, Biochemistry, Fatty acid, Internal medicine
- MeSH
- monocytes, cells, cultured, macrophages, animals, humans, mice, carcinoma, squamous cell, breast neoplasms, inflammation, reactive nitrogen species, reactive oxygen species, docosahexaenoic acids, tumor necrosis factor-alpha, cytokines, liposomes, cell proliferation, oxidative stress, female, human umbilical vein endothelial cells, in vitro techniques
6 authors
From NL, DE
- Amr AlaargUtrecht University; University of Twente
- Nan Yeun JordanUtrecht University; Pharmo Institute; University of Twente
- Johan J. F. VerhoefUtrecht University; Pharmo Institute
- Josbert M. MetselaarUtrecht University; Pharmo Institute; RWTH Aachen University; University of Twente
- Gert StormUtrecht University; Pharmo Institute; University of Twente
- Robbert J. KokUtrecht University; Pharmo Institute
Abstract
Inflammation, oxidative stress, and uncontrolled cell proliferation are common key features of chronic inflammatory diseases, such as atherosclerosis and cancer. ω3 polyunsaturated fatty acids (PUFAs; also known as omega3 fatty acids or fish oil) have beneficial effects against inflammation upon dietary consumption. However, these effects cannot be fully exploited unless diets are enriched with high concentrations of fish oil supplements over long periods of time. Here, a nanomedicine-based approach is presented for delivering effective levels of PUFAs to inflammatory cells. Nanoparticles are internalized by immune cells, and hence can adequately deliver bioactive lipids into these target cells. The ω3 FA docosahexaenoic acid was formulated into liposomes (ω-liposomes), and evaluated for anti-inflammatory effects in different types of immune cells. ω-Liposomes strongly inhibited the release of reactive oxygen species and reactive nitrogen species from human neutrophils and murine macrophages, and also inhibited the production of the proinflammatory cytokines TNFα and MCP1. Moreover, ω-liposomes inhibited tumor-cell proliferation when evaluated in FaDu head and neck squamous carcinoma and 4T1 breast cancer cells in in vitro cultures. We propose that ω-liposomes are a promising nanonutraceutical formulation for intravenous delivery of fish oil FAs, which may be beneficial in the treatment of inflammatory disorders and cancer.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC).
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