Serum 25-hydroxyvitamin D and the risk of stroke in Hong Kong Chinese
Leung RY, Han Y, Sing CW, Cheung BM, Wong IC, Tan KC, Kung AW, Cheung CL
Thrombosis and haemostasis · 28 citations
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Independent funding
- Government
- Health and Medical Research Fund
- Nonprofit
- HMRF
- Grants
- Health and Medical Research Fund (HKU12132451)
Based on 2 listed funder(s).
Publication
- Published
- 2016-10-27 · Thromb Haemost · vol. 117 · issue 01 · pp. 158–163
- Publisher
- Thieme Medical Publishers (Germany)
- Cited
- 36 citations · more than 93% of similar papers · 3.5× the field average
- Impact
- Top 10% most cited in its field
- References
- 43 works
- Access
- Open access (repository copy)
- Research areas
- Vitamin D Research Studies · Bone health and osteoporosis research · Vitamin C and Antioxidants Research
- Keywords
- Stroke (engine), Medicine, Internal medicine, Cardiology
- MeSH
- humans, brain ischemia, vitamin d deficiency, vitamin d, prognosis, multivariate analysis, proportional hazards models, risk assessment, risk factors, chi-square distribution, prospective studies, aged, middle aged, hong kong, female, male, stroke, electronic health records, biomarkers, asian people
8 authors
From HK, GB
- Chor‐Wing SingChinese University of Hong Kong; University of Hong Kong
- Bernard M.Y. CheungChinese University of Hong Kong; University of Hong Kong
- Ian Chi Kei WongChinese University of Hong Kong; University College London; University of Hong Kong
- K. C. B. TanChinese University of Hong Kong; University of Hong Kong
- Annie W.C. KungChinese University of Hong Kong; University of Hong Kong
- Raymond Y.H. Leung
Abstract
Low vitamin D levels have been associated with various cardiovascular diseases; however, whether it is associated with stroke remains inconclusive. We aimed to evaluate the association between serum 25-hydroxyvitamin D and risk of stroke. We conducted a cohort study consisting of 3,458 participants from the Hong Kong Osteoporosis Study aged ≥45 at baseline, examined between 1995 and 2010 and followed up using electronic medical records. Ischaemic and haemorrhagic stroke were defined using the ICD-9 code. In multivariable Cox-proportional hazard regression, quintiles 1 and 4 were significantly associated with increased risk of stroke when compared to the highest quintile (Quintile 1: HR, 1.78; 95 % CI, 1.16-2.74 and quintile 4: HR, 1.61; 95 % CI, 1.07-2.43). A similar association was observed in both men and women. In subgroup analysis, the association was specifically observed for ischaemic stroke, but not haemorrhagic stroke. Using a penalized regression spline, the association between vitamin D and risk of stroke was in a reverse J-shape, with the lowest risk of stroke being observed at 25(OH)D levels between 70 and 80 nmol/l. In conclusion, a low vitamin D level is associated with increased risk of ischaemic stroke; however, whether high vitamin D level is also associated with increased risk of stroke requires further study.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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