Funded in part by Bupa Foundation
Determinants of the Maternal 25-Hydroxyvitamin D Response to Vitamin D Supplementation During Pregnancy
Moon RJ, Harvey NC, Cooper C, D'Angelo S, Crozier SR, Inskip HM, Schoenmakers I, Prentice A, Arden NK, Bishop NJ, Carr A, Dennison EM, Eastell R, Fraser R, Gandhi SV, Godfrey KM, Kennedy S, Mughal MZ, Papageorghiou AT, Reid DM, Robinson SM, Javaid MK
The Journal of clinical endocrinology and metabolism · 37 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Industry funded
- Government
- National Institute for Health and Care Research
- Company
- Bupa Foundation
- Government
- European Commission
- Nonprofit
- Versus Arthritis
- Government
- Medical Research Council
- Government
- National Institute for Health Research (NIHR)
- Grants
- National Institute for Health and Care Research (10/33/04); Medical Research Council (MR/K006312/1); National Institute for Health and Care Research (HTA/10/33/04); National Institute for Health and Care Research (NF-SI-0515-10042); Medical Research Council (MC_UU_12011/4); Versus Arthritis (21231); National Institute for Health and Care Research (NF-SI-0508-10082); Versus Arthritis (19583); Versus Arthritis (17702); Medical Research Council (MC_UU_12011/2); Medical Research Council (MC_UU_12011/1); National Institute for Health and Care Research (NF-SI-0513-10085)
Based on 6 listed funder(s).
Publication
- Published
- 2016-10-27 · J Clin Endocrinol Metab · vol. 101 · issue 12 · pp. 5012–5020
- Publisher
- Oxford University Press
- Cited
- 49 citations · more than 96% of similar papers · 5.3× the field average
- Impact
- Top 10% most cited in its field
- References
- 40 works
- Access
- Open access (hybrid journal) · CC-BY
- Research areas
- Vitamin D Research Studies · Gestational Diabetes Research and Management · Per- and polyfluoroalkyl substances research
- Keywords
- Pregnancy, Vitamin D and neurology, Medicine, Vitamin, vitamin D deficiency, Internal medicine, Endocrinology, Biology, Genetics
- MeSH
- humans, weight gain, cholecalciferol, vitamins, vitamin d, double-blind method, seasons, pregnancy, pregnancy trimesters, adult, female, young adult, outcome assessment, health care
22 authors
From GB
- Rebecca Jane MoonSouthampton General Hospital; University Hospital Southampton NHS Foundation Trust; NIHR Southampton Biomedical Research Centre; MRC Lifecourse Epidemiology Unit; University of Southampton; Medical Research Council
- Nicholas C. HarveyUniversity Hospital Southampton NHS Foundation Trust; National Institute for Health and Care Research; NIHR Southampton Biomedical Research Centre; MRC Lifecourse Epidemiology Unit; University of Southampton; Medical Research Council
- Cyrus Cooper · correspondingUniversity Hospital Southampton NHS Foundation Trust; National Institute for Health and Care Research; NIHR Southampton Biomedical Research Centre; MRC Lifecourse Epidemiology Unit; University of Southampton; Medical Research Council
- Stefania D’AngeloUniversity Hospital Southampton NHS Foundation Trust; NIHR Southampton Biomedical Research Centre; MRC Lifecourse Epidemiology Unit; University of Southampton; Medical Research Council
- Sarah CrozierUniversity Hospital Southampton NHS Foundation Trust; NIHR Southampton Biomedical Research Centre; MRC Lifecourse Epidemiology Unit; University of Southampton; Medical Research Council
- Hazel M. InskipUniversity Hospital Southampton NHS Foundation Trust; NIHR Southampton Biomedical Research Centre; MRC Lifecourse Epidemiology Unit; University of Southampton; Medical Research Council
Abstract
Context
Current approaches to antenatal vitamin D supplementation do not account for interindividual differences in 25-hydroxyvitamin D (25(OH)D) response.
Objective
We assessed which maternal and environmental characteristics were associated with 25(OH)D after supplementation with cholecalciferol.
Design
Within-randomization-group analysis of participants in the Maternal Vitamin D Osteoporosis Study trial of vitamin D supplementation in pregnancy.
Setting
Hospital antenatal clinics.
Participants
A total of 829 pregnant women (422 placebo, 407 cholecalciferol). At 14 and 34 weeks of gestation, maternal anthropometry, health, and lifestyle were assessed and 25(OH)D measured. Compliance was determined using pill counts at 19 and 34 weeks.
Interventions
1000 IU/d of cholecalciferol or matched placebo from 14 weeks of gestation until delivery.
Main outcome measure
25(OH)D at 34 weeks, measured in a single batch (Diasorin Liaison).
Results
25(OH)D at 34 weeks of gestation was higher in the women randomized to vitamin D (mean [SD], 67.7 [21.3] nmol/L) compared with placebo (43.1 [22.5] nmol/L; P < .001). In women randomized to cholecalciferol, higher pregnancy weight gain from 14 to 34 weeks of gestation (kg) (β = -0.81 [95% confidence interval -1.39, -0.22]), lower compliance with study medication (%) (β = -0.28 [-0.072, -0.48]), lower early pregnancy 25(OH)D (nmol/L) (β = 0.28 [0.16, 0.40]), and delivery in the winter vs the summer (β = -10.5 [-6.4, -14.6]) were independently associated with lower 25(OH)D at 34 weeks of gestation.
Conclusions
Women who gained more weight during pregnancy had lower 25(OH)D in early pregnancy and delivered in winter achieved a lower 25(OH)D in late pregnancy when supplemented with 1000 IU/d cholecalciferol. Future studies should aim to determine appropriate doses to enable consistent repletion of 25(OH)D during pregnancy.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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