Dietary supplementation with docosahexaenoic acid (DHA) improves seminal antioxidant status and decreases sperm DNA fragmentation
Martínez-Soto JC, Domingo JC, Cordobilla B, Nicolás M, Fernández L, Albero P, Gadea J, Landeras J
Systems biology in reproductive medicine · 90 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2016-10-28 · Syst Biol Reprod Med · vol. 62 · issue 6 · pp. 387–395
- Publisher
- Taylor & Francis
- Cited
- 129 citations · more than 98% of similar papers · 12.1× the field average
- Impact
- Top 10% most cited in its field
- References
- 49 works
- Access
- Free to read
- Research areas
- Sperm and Testicular Function · Fatty Acid Research and Health · Birth, Development, and Health
- Keywords
- Docosahexaenoic acid, DNA fragmentation, Semen, Sperm, Antioxidant, Sperm motility, Polyunsaturated fatty acid, Biology, Fish oil, Semen quality, Sunflower oil, Fatty acid, Internal medicine, Food science, Biochemistry, Andrology, Medicine, Botany, Anatomy
- MeSH
- spermatozoa, semen, humans, docosahexaenoic acids, placebos, antioxidants, double-blind method, dna fragmentation, dietary supplements, male, lipid metabolism
8 authors
From ES
- Juan Carlos Martínez-Soto · correspondingIVI Murcia Clinic
- Joan Carles DomingoUniversitat de Barcelona
- Begoña CordobillaUniversitat de Barcelona
- M. NicolásIVI Murcia Clinic
- Laura Fernández de CastroIVI Murcia Clinic
- Pilar AlberoIVI Murcia Clinic
Abstract
The purpose of this study was to evaluate the effect of docosahexaenoic acid (DHA) dietary supplementation on semen quality, fatty acid composition, antioxidant capacity, and DNA fragmentation. In this randomized, double blind, placebo-controlled, parallel-group study, 74 subjects were recruited and randomly assigned to either the placebo group (n=32) or to the DHA group (n=42) to consume three 500-mg capsules of oil per day over 10 weeks. The placebo group received 1,500 mg/day of sunflower oil and the DHA group 1,500 mg/day of DHA-enriched oil. Seminal parameters (semen volume, sperm concentration, motility, morphology, and vitality), total antioxidant capacity, deoxyribonucleic acid fragmentation, and lipid composition were evaluated prior to the treatment and after 10 weeks. Finally, 57 subjects were included in the study with 25 in the placebo group and 32 in the DHA group. No differences were found in traditional sperm parameters or lipid composition of the sperm membrane after treatment. However, an increase in DHA and Omega-3 fatty acid content in seminal plasma, an improvement in antioxidant status, and a reduction in the percentage of spermatozoa with deoxyribonucleic acid damage were observed in the DHA group after 10 weeks of treatment.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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