Urinary Biomarkers of Whole Grain Wheat Intake Identified by Non-targeted and Targeted Metabolomics Approaches
Zhu Y, Wang P, Sha W, Sang S
Scientific reports · 37 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Mechanisms only
- Intake measured by
- Intake biomarkers
Who paid for it
- Funding
- Independent funding
- Government
- U.S. Department of Agriculture
- Government
- National Institute of Food and Agriculture
- Grants
- National Institute of Food and Agriculture (2012-38821-20012)
Based on 2 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2016-11-02 · Sci Rep · vol. 6 · issue 1 · p. 36278
- Publisher
- Nature Portfolio
- Cited
- 50 citations · more than 86% of similar papers · 1.9× the field average
- References
- 92 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Metabolomics and Mass Spectrometry Studies · Nutritional Studies and Diet · Nutrition, Genetics, and Disease
- Keywords
- Metabolomics, Biomarker, Endogeny, Whole grains, Medicine, Disease, Biomarker discovery, Biotechnology, Bioinformatics, Physiology, Biology, Internal medicine, Food science, Biochemistry, Proteomics, Gene
- MeSH
- humans, triticum, neoplasms, cardiovascular diseases, chronic disease, resorcinols, benzoxazines, diet, metabolomics, hydroxybenzoates, biomarkers, whole grains
4 authors
From US
- Yingdong ZhuNorth Carolina Agricultural and Technical State University
- Pei WangNorth Carolina Agricultural and Technical State University
- Wei ShaUniversity of North Carolina at Charlotte
- Shengmin SangNorth Carolina Agricultural and Technical State University
Abstract
Mounting evidence suggests that whole grain (WG) intake plays an important role in chronic disease prevention. However, numerous human studies have failed to produce clear-cut conclusions on this topic. Here, a combination of non-targeted and targeted metabolomics approaches, together with kinetic studies, was used to investigate biomarkers of WG wheat intake and further explore the diet-disease associations. Via these integrated approaches, forty-one compounds were identified as the most discriminating endogenous metabolites after WG versus refined grain (RG) wheat bread consumption. The corresponding biological assessment of these endogenous changes suggests that, in contrast to RG consumption, WG wheat consumption may facilitate antioxidant defense systems and moderate the risk factors of cancer, cardiovascular diseases, and other chronic diseases. A panel of urinary markers consisting of seven alkylresorcinol metabolites and five benzoxazinoid derivatives as specific biomarkers, as well as five phenolic acid derivatives, was also established to cover multiple time points and longer time periods for correctly and objectively monitoring WG wheat intake. Through these findings, we have established a comprehensive biomarker pool to better assess WG wheat consumption, and to monitor the endogenous changes that are linked to health effects of WG wheat consumption.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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