Impact of different types of tree nut, peanut, and soy nut consumption on serum C-reactive protein (CRP): A systematic review and meta-analysis of randomized controlled clinical trials
Mazidi M, Rezaie P, Ferns GA, Gao HK
Medicine · 48 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Mechanisms only
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
- University or hospital
- Chinese Academy of Sciences
Based on 1 listed funder(s).
Publication
- Published
- 2016-11-01 · Medicine (Baltimore) · vol. 95 · issue 44 · p. e5165
- Publisher
- Wolters Kluwer
- Cited
- 55 citations · more than 97% of similar papers · 5.8× the field average
- Impact
- Top 10% most cited in its field
- References
- 67 works
- Access
- Open access (journal) · CC-BY-ND
- Research areas
- Nuts composition and effects · Peanut Plant Research Studies · Antioxidant Activity and Oxidative Stress
- Keywords
- Nut, Medicine, C-reactive protein, Adiponectin, Meta-analysis, Prospective cohort study, Confidence interval, Food science, Internal medicine, Obesity, Biology
- MeSH
- humans, nuts, c-reactive protein, diet, prospective studies, randomized controlled trials as topic, arachis, glycine max
4 authors
From CN, IR, GB
- Mohsen MazidiChinese Academy of Sciences; Institute of Genetics and Developmental Biology
- Peyman RezaieMashhad University of Medical Sciences
- Gordon A. FernsBrighton and Sussex Medical School; University of Brighton
- Hongkai Gao · correspondingChinese People's Armed Police General Hospital; Chinese People's Armed Police Force
Abstract
Background
The effects of different types of tree nut, peanut, and soy nut consumption on serum C - reactive protein (CRP) are not well established. we aimed to undertake a systematic review and meta-analysis of prospective studies to determine the effect of nut consumption (tree nuts, peanuts, and soy nuts) on serum CRP.
Method
PubMed-Medline, Web of Science, Cochrane Database, and Google Scholar databases were searched (up until April 20 2016) to identify prospective studies evaluating the impact of tree nut, peanut, and soy nut consumption on serum CRP. Random effects models meta-analysis was used for quantitative data synthesis. Sensitivity analysis was conducted using the leave-one-out method. Heterogeneity was quantitatively assessed using the I index. Systematic review registration: CRD42016038044.
Results
From a total of 844 entries identified via searches, 20 studies were included in the final selection. The meta-analysis indicated a nonsignificant increase in serum CRP concentrations following nut consumption (weighted mean difference [WMD] 0.17 mg/L, (95% CI -0.67 to 0.33, I 52.1%). The WMDs for IL6 was -0.06(ng/dL), (95% CI -0.69 to 0.56, I 9.6%), -0.71(mg/dL), (95% CI -1.11 to -0.30, I 6.3%), for leptin, and -0.60(mg/dL), (95% CI -1.88 to 0.68, I 5.6%) for adiponectin, and -0.18(mg/dL), (95% CI -1.24 to 0.88, I 9.3%) for IL10 and -0.37 (pg/mL), (95% CI -0.90 to 0.16, I 7.9%) for TNF-α. These findings were robust in sensitivity analyses.
Conclusions
This meta-analysis suggests that nut consumption significantly decrease leptin while have no significant effect on CRP, IL6, adiponectin, IL10, and TNF-α.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-ND).
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