Funded in part by Santander International Mobility Grant
Effects of caffeine on neuromuscular fatigue and performance during high-intensity cycling exercise in moderate hypoxia
Smirmaul BP, de Moraes AC, Angius L, Marcora SM
European journal of applied physiology · 42 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Industry funded
- Government
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- University or hospital
- Universidade Estadual de Campinas
- Company
- Santander International Mobility Grant
- Grants
- Conselho Nacional de Desenvolvimento Científico e Tecnológico (131724/2011-8)
Based on 3 listed funder(s).
Publication
- Published
- 2016-11-18 · Eur J Appl Physiol · vol. 117 · issue 1 · pp. 27–38
- Publisher
- Springer Science+Business Media
- Cited
- 68 citations · more than 88% of similar papers · 2.3× the field average
- References
- 55 works
- Access
- Open access (hybrid journal) · CC-BY
- Research areas
- Coffee research and impacts · High Altitude and Hypoxia · Chronic Obstructive Pulmonary Disease (COPD) Research
- Keywords
- Caffeine, Cycling, Placebo, Heart rate, Hypoxia (environmental), Medicine, Sports medicine, Physical therapy, VO2 max, Muscle fatigue, Exercise physiology, Cardiology, Internal medicine, Physical medicine and rehabilitation, Anesthesia, Electromyography, Blood pressure, Oxygen, Chemistry
- MeSH
- muscle, skeletal, humans, caffeine, central nervous system stimulants, exercise, muscle fatigue, adult, male, athletic performance, hypoxia
4 authors
From BR, GB
- Bruno Paula Caraça SmirmaulUniversidade Estadual Paulista (Unesp)
- Antônio Carlos de MoraesUniversidade Estadual de Campinas (UNICAMP)
- Luca AngiusUniversity of Kent
- Samuele Marcora · correspondingMedway School of Pharmacy; University of Kent
Abstract
Purpose
To investigate the effects of caffeine on performance, neuromuscular fatigue and perception of effort during high-intensity cycling exercise in moderate hypoxia.
Methods
Seven adult male participants firstly underwent an incremental exercise test on a cycle ergometer in conditions of acute normobaric hypoxia (fraction inspired oxygen = 0.15) to establish peak power output (PPO). In the following two visits, they performed a time to exhaustion test (78 ± 3% PPO) in the same hypoxic conditions after caffeine ingestion (4 mg kg-1) and one after placebo ingestion in a double-blind, randomized, counterbalanced cross-over design.
Results
Caffeine significantly improved time to exhaustion by 12%. A significant decrease in subjective fatigue was found after caffeine consumption. Perception of effort and surface electromyographic signal amplitude of the vastus lateralis were lower and heart rate was higher in the caffeine condition when compared to placebo. However, caffeine did not reduce the peripheral and central fatigue induced by high-intensity cycling exercise in moderate hypoxia.
Conclusion
The caffeine-induced improvement in time to exhaustion during high-intensity cycling exercise in moderate hypoxia seems to be mediated by a reduction in perception of effort, which occurs despite no reduction in neuromuscular fatigue.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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