Effects of dietary restriction on adipose mass and biomarkers of healthy aging in human
Lettieri-Barbato D, Giovannetti E, Aquilano K
Aging · 43 citations
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- Ministero della Salute
- University or hospital
- Università degli Studi di Roma Tor Vergata
- Grants
- Ministero della Salute (GR-2011-02348047)
Based on 2 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2016-11-29 · Aging (Albany NY) · vol. 8 · issue 12 · pp. 3341–3355
- Publisher
- Impact Journals LLC
- Cited
- 59 citations · more than 94% of similar papers · 4.1× the field average
- Impact
- Top 10% most cited in its field
- References
- 88 works
- Access
- Open access (repository copy) · OTHER-OA
- Research areas
- Dietary Effects on Health · Diet and metabolism studies · Genetics, Aging, and Longevity in Model Organisms
- Keywords
- Adiponectin, Calorie restriction, Leptin, Medicine, Obesity, Calorie, Adipokine, Adipose tissue, Metabolic syndrome, Low calorie diet, Psychological intervention, Biomarker, Internal medicine, Physiology, Endocrinology, Bioinformatics, Weight loss, Insulin resistance, Biology
- MeSH
- adipose tissue, humans, inflammation, dehydroepiandrosterone, insulin, insulin-like growth factor i, cytokines, caloric restriction, protein footprinting, gene expression regulation, aging, adipokines, biomarkers
3 authors
From IT
- Daniele Lettieri‐Barbato · correspondingUniversity of Rome Tor Vergata
- Esmeralda GiovannettiUniversity of Rome Tor Vergata
- Katia AquilanoUniversity of Rome Tor Vergata; IRCCS Ospedale San Raffaele; Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele
Abstract
In developing countries the rise of obesity and obesity-related metabolic disorders, such as cardiovascular diseases and type 2 diabetes, reflects the changes in lifestyle habits and wrong dietary choices. Dietary restriction (DR) regimens have been shown to extend health span and lifespan in many animal models including primates. Identifying biomarkers predictive of clinical benefits of treatment is one of the primary goals of precision medicine. To monitor the clinical outcomes of DR interventions in humans, several biomarkers are commonly adopted. However, a validated link between the behaviors of such biomarkers and DR effects is lacking at present time. Through a systematic analysis of human intervention studies, we evaluated the effect size of DR (i.e. calorie restriction, very low calorie diet, intermittent fasting, alternate day fasting) on health-related biomarkers. We found that DR is effective in reducing total and visceral adipose mass and improving inflammatory cytokines profile and adiponectin/leptin ratio. By analysing the levels of canonical biomarkers of healthy aging, we also validated the changes of insulin, IGF-1 and IGFBP-1,2 to monitor DR effects. Collectively, we developed a useful platform to evaluate the human responses to dietary regimens low in calories.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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