Vitamin D Status and Efficacy of Vitamin D Supplementation in Atopic Dermatitis: A Systematic Review and Meta-Analysis
Kim MJ, Kim SN, Lee YW, Choe YB, Ahn KJ
Nutrients · 82 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2016-12-03 · Nutrients · vol. 8 · issue 12 · p. 789
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 151 citations · more than 86% of similar papers · 2.3× the field average
- References
- 39 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Dermatology and Skin Diseases · Allergic Rhinitis and Sensitization · Urticaria and Related Conditions
- Keywords
- SCORAD, Atopic dermatitis, Medicine, Vitamin D and neurology, Internal medicine, Strictly standardized mean difference, Confidence interval, Meta-analysis, Randomized controlled trial, Gastroenterology, Vitamin, Observational study, Cochrane Library, Dermatology, Disease, Dermatology Life Quality Index
- MeSH
- humans, dermatitis, atopic, vitamins, vitamin d, nutrition therapy, severity of illness index, dietary supplements, adolescent, adult, middle aged, child, child, preschool, female, male, randomized controlled trials as topic, young adult, observational studies as topic
5 authors
From KR
- Min Joung KimKonkuk University
- Soo‐Nyung KimKonkuk University
- Yang Lee · correspondingKonkuk University; Konkuk University Medical Center
- Yong Kyung ChoeKonkuk University; Konkuk University Medical Center
- Kyu Joong AhnKonkuk University; Konkuk University Medical Center
Abstract
Recent literature has highlighted the possible role of vitamin D in atopic dermatitis (AD), and that vitamin D supplementation might help to treat AD. This study determined the relationship between vitamin D level and AD, and assessed the efficacy of vitamin D supplementation. We searched the MEDLINE, EMBASE, and Cochrane databases up to May 2015. Observational studies and randomized controlled trials were included based on the available data on the serum 25-hydroxyvitamin D (25(OH)D) level and quantified data available for severity assessed using the Scoring Atopic Dermatitis (SCORAD) index or Eczema Area and Severity Index (EASI) score. Compared with healthy controls, the serum 25(OH)D level was lower in the AD patients of all ages (standardized mean difference = -2.03 ng/mL; 95% confidence interval (CI) = -2.52 to -0.78), and predominantly in the pediatric AD patients (standardized mean difference = -3.03 ng/mL; 95% CI = -4.76 to -1.29). In addition, the SCORAD index and EASI score decreased after vitamin D supplementation (standardized mean difference = -5.85; 95% CI = -7.66 to -4.05). This meta-analysis showed that serum vitamin D level was lower in the AD patients and vitamin D supplementation could be a new therapeutic option for AD.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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