Dietary magnesium intake and the risk of cardiovascular disease, type 2 diabetes, and all-cause mortality: a dose-response meta-analysis of prospective cohort studies
Fang X, Wang K, Han D, He X, Wei J, Zhao L, Imam MU, Ping Z, Li Y, Xu Y, Min J, Wang F
BMC medicine · 179 citations
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Independent funding
- Government
- National Natural Science Foundation of China
- Government
- Natural Science Foundation of Zhejiang Province
- Grants
- Natural Science Foundation of Zhejiang Province (LZ15H160002); National Natural Science Foundation of China (31330036); National Natural Science Foundation of China (31401016); National Natural Science Foundation of China (31530034); National Natural Science Foundation of China (31570791); National Natural Science Foundation of China (91542205); National Natural Science Foundation of China (31225013)
Based on 2 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2016-12-01 · BMC Med · vol. 14 · issue 1 · p. 210
- Publisher
- BioMed Central
- Cited
- 266 citations · more than 96% of similar papers · 4.5× the field average
- Impact
- Top 10% most cited in its field
- References
- 85 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Magnesium in Health and Disease · Parathyroid Disorders and Treatments · Magnesium Alloys: Properties and Applications
- Keywords
- Medicine, Prospective cohort study, Relative risk, Internal medicine, Type 2 diabetes, Cohort study, Meta-analysis, Diabetes mellitus, Stroke (engine), Cohort, Confidence interval, Endocrinology
- MeSH
- humans, cardiovascular diseases, diabetes mellitus, type 2, magnesium, trace elements, survival analysis, prospective studies, dose-response relationship, drug, statistics as topic
12 authors
From CN
- Xuexian FangBeijing Advanced Innovation Center for Food Nutrition and Human Health
- Kai WangZhejiang University
- Dan HanBeijing Advanced Innovation Center for Food Nutrition and Human Health
- Xuyan HeBeijing Advanced Innovation Center for Food Nutrition and Human Health
- Jiayu WeiBeijing Advanced Innovation Center for Food Nutrition and Human Health
- Lu ZhaoBeijing Advanced Innovation Center for Food Nutrition and Human Health
Abstract
Background
Although studies have examined the association between dietary magnesium intake and health outcome, the results are inconclusive. Here, we conducted a dose-response meta-analysis of prospective cohort studies in order to investigate the correlation between magnesium intake and the risk of cardiovascular disease (CVD), type 2 diabetes (T2D), and all-cause mortality.
Methods
PubMed, EMBASE, and Web of Science were searched for articles that contained risk estimates for the outcomes of interest and were published through May 31, 2016. The pooled results were analyzed using a random-effects model.
Results
Forty prospective cohort studies totaling more than 1 million participants were included in the analysis. During the follow-up periods (ranging from 4 to 30 years), 7678 cases of CVD, 6845 cases of coronary heart disease (CHD), 701 cases of heart failure, 14,755 cases of stroke, 26,299 cases of T2D, and 10,983 deaths were reported. No significant association was observed between increasing dietary magnesium intake (per 100 mg/day increment) and the risk of total CVD (RR: 0.99; 95% CI, 0.88-1.10) or CHD (RR: 0.92; 95% CI, 0.85-1.01). However, the same incremental increase in magnesium intake was associated with a 22% reduction in the risk of heart failure (RR: 0.78; 95% CI, 0.69-0.89) and a 7% reduction in the risk of stroke (RR: 0.93; 95% CI, 0.89-0.97). Moreover, the summary relative risks of T2D and mortality per 100 mg/day increment in magnesium intake were 0.81 (95% CI, 0.77-0.86) and 0.90 (95% CI, 0.81-0.99), respectively.
Conclusions
Increasing dietary magnesium intake is associated with a reduced risk of stroke, heart failure, diabetes, and all-cause mortality, but not CHD or total CVD. These findings support the notion that increasing dietary magnesium might provide health benefits.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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