Ultra-Processed Food Consumption and the Incidence of Hypertension in a Mediterranean Cohort: The Seguimiento Universidad de Navarra Project
Mendonça RD, Lopes AC, Pimenta AM, Gea A, Martinez-Gonzalez MA, Bes-Rastrollo M
American journal of hypertension · 332 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Food frequency questionnaire
Who paid for it
- Funding
- Independent funding
- Government
- Ministry of Education
- Government
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Government
- European Regional Development Fund
Based on 3 listed funder(s).
Publication
- Published
- 2016-10-14 · Am J Hypertens · vol. 30 · issue 4 · pp. 358–366
- Publisher
- Oxford University Press
- Cited
- 501 citations · more than 100% of similar papers · 24.8× the field average
- Impact
- Top 10% most cited in its field
- References
- 52 works
- Access
- Paywalled
- Research areas
- Consumer Attitudes and Food Labeling · Culinary Culture and Tourism · Health, Technology, Consumer Behavior
- Keywords
- Medicine, Hazard ratio, Prospective cohort study, Cohort, Incidence (geometry), Confounding, Proportional hazards model, Confidence interval, Cohort study, Food group, Obesity, Mediterranean diet, Internal medicine, Environmental health
- MeSH
- humans, hypertension, obesity, weight gain, diet, incidence, proportional hazards models, cohort studies, longitudinal studies, follow-up studies, prospective studies, age factors, food handling, adult, middle aged, spain, female, male, young adult
6 authors
From BR, ES, US
- Raquel de Deus MendonçaUniversidade Federal de Minas Gerais; Ministry of Education; Coordenação de Aperfeicoamento de Pessoal de Nível Superior; Universidad de Navarra
- Aline Cristine Souza LopesUniversidade Federal de Minas Gerais
- Adriano Marçal PimentaUniversidade Federal de Minas Gerais; Universidad de Navarra
- Alfredo GeaInstituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Navarre Institute of Health Research; Universidad de Navarra
- Miguel Ángel Martínez‐GonzálezHarvard University; Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Navarre Institute of Health Research; Universidad de Navarra
- Maira Bes‐RastrolloInstituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Navarre Institute of Health Research; Universidad de Navarra
Abstract
Background
Some available evidence suggests that high consumption of ultra-processed foods (UPFs) is associated with a higher risk of obesity. Collectively, this association and the nutritional characteristics of UPFs suggest that UPFs might also be associated with hypertension.
Methods
We prospectively evaluated the relationship between UPF consumption and the risk of hypertension in a prospective Spanish cohort, the Seguimiento Universidad de Navarra project. We included 14,790 Spanish adult university graduates who were initially free of hypertension at baseline who were followed for a mean of 9.1 years (SD, 3.9 years; total person-years: 134,784). UPF (industrial formulations of chemical compounds which, beyond substances of common culinary use such as salt, sugar, oils, and fats, include substances also derived from foods but not used in culinary preparations) consumption was assessed using a validated semi-quantitative 136-item food-frequency questionnaire. Cox proportional hazards models were used to estimate adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for hypertension incidence.
Results
During follow-up, 1,702 incident cases of hypertension were identified. Participants in the highest tertile of UPF consumption had a higher risk of developing hypertension (adjusted HR, 1.21; 95% CI, 1.06, 1.37; P for trend = 0.004) than those in the lowest tertile after adjusting for potential confounders.
Conclusions
In this large prospective cohort of Spanish middle-aged adult university graduates, a positive association between UPF consumption and hypertension risk was observed. Additional longitudinal studies are needed to confirm our results.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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