Stabilized sulforaphane for clinical use: Phytochemical delivery efficiency
Fahey JW, Wade KL, Wehage SL, Holtzclaw WD, Liu H, Talalay P, Fuchs E, Stephenson KK
Molecular nutrition & food research · 60 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- In vitro/mechanistic study (classified by our AI screen)
- Studied in
- People, plus animal or lab work
- Main outcome
- Mechanisms only
Who paid for it
- Funding
- Independent funding
- Nonprofit
- Lewis B. and Dorothy Cullman Foundation
- Government
- U.S. Food and Drug Administration
Based on 2 listed funder(s).
Publication
- Published
- 2016-12-09 · Mol Nutr Food Res · vol. 61 · issue 4
- Publisher
- Wiley
- Cited
- 78 citations · more than 96% of similar papers · 4.6× the field average
- Impact
- Top 10% most cited in its field
- References
- 58 works
- Access
- Paywalled
- Research areas
- Genomics, phytochemicals, and oxidative stress · Curcumin's Biomedical Applications · Advanced Glycation End Products research
- Keywords
- Sulforaphane, Phytochemical, Bioavailability, Isothiocyanate, Chemistry, Pharmacology, Medicine, Biochemistry
- MeSH
- animals, humans, mice, brassica, oximes, thiocyanates, imidoesters, isothiocyanates, sulfoxides, alpha-cyclodextrins, glucosinolates, anticarcinogenic agents, biological availability, dietary supplements, phytochemicals
8 authors
From US
- Jed W. Fahey · correspondingJohns Hopkins University; Johns Hopkins Medicine
- Kristina L. WadeJohns Hopkins University; Johns Hopkins Medicine
- Scott L. WehageJohns Hopkins University; Becton Dickinson (United States); Johns Hopkins Medicine
- Walter David HoltzclawJohns Hopkins University; Johns Hopkins Medicine
- Hua LiuJohns Hopkins University; Johns Hopkins Medicine
- Paul TalalayJohns Hopkins University; Johns Hopkins Medicine
Abstract
Scope
The isothiocyanate sulforaphane (SF) from broccoli is one of the most potent known inducers of the cytoprotective phase 2 response. Its role in a host of biochemical pathways makes it a major component of plant-based protective strategies for enhancing healthspan. Many nutritional supplements are now marketed that purport to contain SF, which in plants exists as a stable precursor, a thioglucoside hydroxysulfate. However, SF in pure form must be stabilized for use in supplements.
Methods and results
We evaluated the stability and bioavailability of two stabilized SF preparations-an α-cyclodextrin inclusion (SF-αCD), and an SF-rich, commercial nutritional supplement. SF-αCD area-under-the-curve peak serum concentrations occurred at 2 h, but six of ten volunteers complained of mild stomach upset. After topical application it was not effective in upregulating cytoprotective enzymes in the skin of SKH1 mice whereas pure SF was effective in doing so. Both of these "stabilized" SF preparations were as potent as pure SF in inducing the cytoprotective response in cultured cells, and they were more stable and as bioavailable.
Conclusion
Our studies of a stabilized phytochemical component of foods should encourage further examination of similar products for their utility in chronic disease prevention and therapy.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
Community trust
Loading…
How much do you trust this study's findings?
Comments
Sign in to rate, comment on or flag this study.Sign inSomething wrong here?
Flag this study if its information, labels or funding look wrong. An editor reviews every flag.
Sign in to rate, comment on or flag this study.Sign inEducational information about published research. Not medical advice, and not a recommendation to start or stop anything.