Parenteral Fish-Oil Lipid Emulsions in the Prevention of Severe Retinopathy of Prematurity: A Systematic Review and Meta-Analysis
Vayalthrikkovil S, Bashir RA, Rabi Y, Amin H, Spence JM, Robertson HL, Lodha A
American journal of perinatology · 47 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2016-12-19 · Am J Perinatol · vol. 34 · issue 07 · pp. 705–715
- Publisher
- Thieme Medical Publishers (Germany)
- Cited
- 53 citations · more than 91% of similar papers · 3.1× the field average
- Impact
- Top 10% most cited in its field
- References
- 0 works
- Access
- Paywalled
- Research areas
- Retinopathy of Prematurity Studies · Neonatal Respiratory Health Research · Metabolism and Genetic Disorders
- Keywords
- Retinopathy of prematurity, Medicine, Bronchopulmonary dysplasia, Necrotizing enterocolitis, Intraventricular hemorrhage, Randomized controlled trial, Incidence (geometry), Observational study, Sepsis, Pediatrics, Fish oil, Internal medicine, Gestational age, Pregnancy
- MeSH
- humans, enterocolitis, necrotizing, bronchopulmonary dysplasia, retinopathy of prematurity, fat emulsions, intravenous, fish oils, parenteral nutrition, infant, newborn, infant, low birth weight, infant, premature, randomized controlled trials as topic
7 authors
From CA
- Sakeer VayalthrikkovilUniversity of Calgary
- Rani Ameena BashirUniversity of Calgary
- Yacov RabiUniversity of Calgary; Alberta Children's Hospital
- Harish J. AminUniversity of Calgary; Alberta Children's Hospital
- Jill-Marie SpenceUniversity of Calgary
- Helen RobertsonUniversity of Calgary
Abstract
Objective Omega-3 fatty acids are vital for brain and retinal maturation. It is not clear if early use of ω-3 fatty acids in the form of fish-oil lipid emulsions (FLEs) prevents retinopathy of prematurity (ROP) in preterm infants. The aim of this meta-analysis is to evaluate whether early administration of parenteral FLEs reduces ROP requiring laser therapy or severe ROP ≥stage 3 in preterm infants. Methods A literature search was performed to identify studies comparing parenteral FLEs with soybean-based lipid emulsions (SLEs) in preventing ROP. The main outcome was incidence of severe ROP or ROP requiring laser therapy. Results Studies met the inclusion criteria (four RCTs and two observational studies). The pooled relative risk of ROP requiring laser therapy or severe ROP ≥ stage 3 in FLEs group was 0.47 [95% CI: 0.24-0.90] and 0.40 [95% CI: 0.22-0.76] in RCTs and observational studies, respectively. FLEs also reduced cholestasis; however, other secondary outcomes of bronchopulmonary dysplasia (BPD), necrotizing enterocolitis (NEC), sepsis, intraventricular hemorrhage (IVH), and mortality were similar. Conclusion The use of FLEs may reduce the incidence of severe ROP or need for laser therapy in preterm infants. A large multicenter RCT is required to confirm this.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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