Acute caffeine ingestion reduces insulin sensitivity in healthy subjects: a systematic review and meta-analysis
Shi X, Xue W, Liang S, Zhao J, Zhang X
Nutrition journal · 54 citations
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- National Natural Science Foundation of China
- University or hospital
- Zhengzhou University
- University or hospital
- First Affiliated Hospital of Zhengzhou University
- Grants
- National Natural Science Foundation of China (71673254)
Based on 3 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2016-12-01 · Nutr J · vol. 15 · issue 1 · p. 103
- Publisher
- BioMed Central
- Cited
- 92 citations · more than 76% of similar papers · 1.2× the field average
- References
- 52 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Coffee research and impacts · Circadian rhythm and melatonin · Tea Polyphenols and Effects
- Keywords
- Medicine, Caffeine, Meta-analysis, Cochrane Library, Placebo, Glycemic, Ingestion, Diabetes mellitus, Insulin, Randomized controlled trial, Internal medicine, Confidence interval, Glucose homeostasis, Insulin resistance, Endocrinology, Alternative medicine
- MeSH
- humans, diabetes mellitus, type 2, insulin resistance, caffeine, insulin, blood glucose, risk factors, coffee, randomized controlled trials as topic
5 authors
From CN
- Xiuqin ShiFirst Affiliated Hospital of Zhengzhou University
- Wenhua XueFirst Affiliated Hospital of Zhengzhou University
- Shuhong LiangFirst Affiliated Hospital of Zhengzhou University
- Jie Zhao · correspondingFirst Affiliated Hospital of Zhengzhou University
- Xiaojian Zhang · correspondingFirst Affiliated Hospital of Zhengzhou University
Abstract
Background
According to previous meta-analyses, coffee consumption reduces the risk of type 2 diabetes mellitus. However, the underlying mechanism remains unknown. Whether caffeine, the key ingredient in coffee, has a beneficial effect on the glycemic homeostasis and the anti-diabetic effect is particularly controversial. The aim of this study was to summarize the effect of acute caffeine ingestion on insulin sensitivity in healthy men.
Methods
A comprehensive literature search for papers published before April 2016 was conducted in EMBASE, PubMed, and Cochrane Library databases. Randomized controlled trials (RCTs) that investigated the effect of caffeine on insulin sensitivity in healthy humans without diabetes were included. A random effects meta-analysis was conducted using Review Manager 5.3.
Results
The search yielded 7 RCTs in which caffeine intake was the single variant. Compared with placebo, caffeine intake significantly decreased the insulin sensitivity index, with a standardized mean difference of -2.06 (95% confidence interval -2.67 to -1.44, I2 = 49%, P for heterogeneity = 0.06).
Conclusion
Acute caffeine ingestion reduces insulin sensitivity in healthy subjects. Thus, in the short term, caffeine might shift glycemic homeostasis toward hyperglycemia. Long-term trials investigating the role of caffeine in the anti-diabetic effect of coffee are needed.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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