Effects of different degrees of insulin resistance on endothelial function in obese adults undergoing alternate day fasting
Hoddy KK, Bhutani S, Phillips SA, Varady KA
Nutrition and healthy aging · 21 citations
How it was studied
- Design
- Controlled clinical trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- University or hospital
- University of Illinois at Urbana-Champaign
Based on 1 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2016-10-19 · Nutr Healthy Aging · vol. 4 · issue 1 · pp. 63–71
- Publisher
- IOS Press
- Cited
- 35 citations · more than 82% of similar papers · 1.5× the field average
- References
- 26 works
- Access
- Open access (hybrid journal) · CC-BY-NC
- Research areas
- Dietary Effects on Health · Diet and metabolism studies · Nutritional Studies and Diet
- Keywords
- Insulin resistance, Internal medicine, Medicine, Endocrinology, Leptin, Insulin, Adiponectin, Obesity, Endothelial dysfunction, Insulin sensitivity, Homeostasis, Homeostatic model assessment
4 authors
From US
- Kristin K. HoddyUniversity of Illinois Chicago
- Surabhi BhutaniUniversity of Illinois Chicago
- Shane Aaron PhillipsUniversity of Illinois Chicago
- Krista A Varady · correspondingUniversity of Illinois Chicago
Abstract
BACKGROUND: Obesity can have deleterious effects on insulin sensitivity leading to endothelial dysfunction. Whether alternate day fasting (ADF) can ameliorate insulin sensitivity in a way that improves endothelial function remains unknown. OBJECTIVE: This study examined the impact of ADF on endothelium dependent flow mediated dilation (FMD) in obese subjects with different degrees of insulin resistance. METHODS: Obese non-diabetic adults (n = 54) participated in an 8-week ADF protocol (25% energy intake "fast day", alternated with ad libitum intake "feast day"). Subjects were divided into tertiles according to degree of insulin resistance based on HOMA-IR (Homeostatic model assessment-Insulin resistance): tertile 1 (0.8-2.4), tertile 2 (2.5-3.6), tertile 3 (3.7-12.4). RESULTS: Body weight decreased (P P P P CONCLUSION: Our data suggest that ADF may be effective for decreasing insulin resistance in insulin resistant subjects, but these changes have no effect on endothelial function.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC).
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