Red and processed meat consumption and risk of bladder cancer: a dose-response meta-analysis of epidemiological studies
Crippa A, Larsson SC, Discacciati A, Wolk A, Orsini N
European journal of nutrition · 46 citations
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
- University or hospital
- Karolinska Institutet
- University or hospital
- Karolinska Institutet (SE)
Based on 2 listed funder(s).
Publication
- Published
- 2016-12-21 · Eur J Nutr · vol. 57 · issue 2 · pp. 689–701
- Publisher
- Springer Science+Business Media
- Cited
- 70 citations · more than 68% of similar papers · 0.9× the field average
- References
- 57 works
- Access
- Open access (hybrid journal) · CC-BY
- Research areas
- Nutritional Studies and Diet · Edible Oils Quality and Analysis · Bladder and Urothelial Cancer Treatments
- Keywords
- Bladder cancer, Medicine, Red meat, Relative risk, Meta-analysis, Cohort study, Epidemiology, Confidence interval, Prospective cohort study, Processed meat, Case-control study, Internal medicine, Cancer, Cohort, Environmental health, Oncology, Pathology, Food science, Biology
- MeSH
- animals, cattle, sheep, domestic, sus scrofa, humans, diet, incidence, risk factors, reproducibility of results, evidence-based medicine, meat, meat products, urinary bladder neoplasms, food, preserved
5 authors
From SE
- Alessio Crippa · correspondingKarolinska Institutet
- Susanna C. LarssonKarolinska Institutet
- Andrea DiscacciatiKarolinska Institutet
- Alicja WolkKarolinska Institutet
- Nicola OrsiniKarolinska Institutet
Abstract
Background/objectives
Several epidemiological studies have analyzed the associations between red and processed meat and bladder cancer risk but the shape and strength of the associations are still unclear. Therefore, we conducted a dose-response meta-analysis to quantify the potential association between red and processed meat and bladder cancer risk.
Methods
Relevant studies were identified by searching the PubMed database through January 2016 and reviewing the reference lists of the retrieved articles. Results were combined using random-effects models.
Results
Five cohort studies with 3262 cases and 1,038,787 participants and 8 cases-control studies with 7009 cases and 27,240 participants met the inclusion criteria. Red meat was linearly associated with bladder cancer risk in case-control studies, with a pooled RR of 1.51 (95% confidence interval (CI) 1.13, 2.02) for every 100 g increase per day, while no association was observed among cohort studies (P heterogeneity across study design = 0.02). Based on both case-control and cohort studies, the pooled relative risk (RR) for every 50 g increase of processed meat per day was 1.20 (95% CI 1.06, 1.37) (P heterogeneity across study design = 0.22).
Conclusions
This meta-analysis suggests that processed meat may be positively associated with bladder cancer risk. A positive association between red meat and risk of bladder cancer was observed only in case-control studies, while no association was observe in prospective studies.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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