Hydroxytyrosol and the Colonic Metabolites Derived from Virgin Olive Oil Intake Induce Cell Cycle Arrest and Apoptosis in Colon Cancer Cells
López de Las Hazas MC, Piñol C, Macià A, Motilva MJ, Motilva MJ
Journal of agricultural and food chemistry · 56 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- In vitro/mechanistic study (classified by our AI screen)
- Studied in
- Cells or lab samples
- Main outcome
- Mechanisms only
Who paid for it
- Funding
- Independent funding
- University or hospital
- Universitat de Lleida
- University or hospital
- University of Lleida (Lleida, Spain)
- Government
- Spanish Ministry of Education and Science
Based on 3 listed funder(s).
Publication
- Published
- 2017-01-10 · J Agric Food Chem · vol. 65 · issue 31 · pp. 6467–6476
- Publisher
- American Chemical Society
- Cited
- 82 citations · more than 95% of similar papers · 4.0× the field average
- Impact
- Top 10% most cited in its field
- References
- 61 works
- Access
- Paywalled
- Research areas
- Edible Oils Quality and Analysis · Phytochemicals and Antioxidant Activities · Tannin, Tannase and Anticancer Activities
- Keywords
- Hydroxytyrosol, Apoptosis, Chemistry, Phenols, Cell cycle, Phenylacetic acid, Biochemistry, Catechol, Colorectal cancer, Food science, Cancer, Biology, Polyphenol, Antioxidant
- MeSH
- colon, caco-2 cells, ht29 cells, humans, olea, colonic neoplasms, phenylethyl alcohol, apoptosis, cell cycle checkpoints, olive oil
4 authors
From ES
- María‐Carmen López de las Hazas · correspondingUniversitat de Lleida
- Carme PiñolUniversitat de Lleida; Instituto de Investigación Biomédica de Lleida
- Alba MaciàUniversitat de Lleida
- Maria-José MotilvaUniversitat de Lleida
Abstract
After the sustained consumption of virgin olive oil (VOO), the unabsorbed native phenols (mainly hydroxytyrosol (HT)) are transformed into its catabolites in the intestine by microbials. The role of these catabolites in preventing colon cancer has not been sufficiently investigated. This work aims to study the antiproliferative and apoptotic activities in colon (Caco-2; HT-29) cancer cell lines of the main catabolites detected in human feces (phenylacetic, phenylpropionic, hydroxyphenylpropionic, and dihydroxyphenylpropionic acids and catechol), after the sustained VOO intake. Additionally, an assessment of the ability of these colonic cells to metabolize the studied compounds was performed. The results showed that HT and phenylacetic and hydroxyphenylpropionic acids produce cell cycle arrest and promote apoptosis. HT-29 cells were more sensitive to phenol treatments than Caco-2. In synthesis, the results of the present study represent a good starting point for understanding the potential apoptotic and antiproliferative effects of VOO phenolic compounds and their colonic metabolites.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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