Nut Consumption and Lung Cancer Risk: Results from Two Large Observational Studies
Lee JT, Lai GY, Liao LM, Subar AF, Bertazzi PA, Pesatori AC, Freedman ND, Landi MT, Lam TK
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 16 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Food frequency questionnaire
Who paid for it
- Funding
- Independent funding
- Nonprofit
- American Association for Cancer Research
- Government
- U.S. Department of Agriculture
- Government
- Regione Lombardia
- Government
- National Institutes of Health
- Government
- Intramural NIH HHS
- Grants
- National Institutes of Health (Z99 CA999999)
Based on 5 listed funder(s).
Publication
- Published
- 2017-01-11 · Cancer Epidemiol Biomarkers Prev · vol. 26 · issue 6 · pp. 826–836
- Publisher
- American Association for Cancer Research
- Cited
- 27 citations · more than 93% of similar papers · 3.4× the field average
- Impact
- Top 10% most cited in its field
- References
- 51 works
- Access
- Open access (repository copy)
- Research areas
- Nuts composition and effects · Nutritional Studies and Diet · Peanut Plant Research Studies
- Keywords
- Observational study, Lung cancer, Medicine, Consumption (sociology), Nut, Internal medicine, Environmental health, Oncology, Engineering
- MeSH
- humans, nuts, lung neoplasms, risk factors, case-control studies, retrospective studies, prospective studies, female, male
9 authors
From US, IT
- Jennifer T. LeeNational Institutes of Health
- Gabriel Y. LaiNational Institutes of Health
- Linda M. LiaoNational Institutes of Health
- Amy F. SubarNational Institutes of Health
- Pier Alberto BertazziUniversity of Milan; Ospedale Maggiore; Istituti di Ricovero e Cura a Carattere Scientifico
- Angela Cecilia PesatoriUniversity of Milan; Ospedale Maggiore; Istituti di Ricovero e Cura a Carattere Scientifico
Abstract
Background: Epidemiologic evidence on the association between nut consumption and lung cancer risk is limited.Methods: We investigated this relationship in the Environment and Genetics in Lung Cancer Etiology (EAGLE) study, a population-based case-control study, and the National Institutes of Health (NIH) American Association of Retired Persons (AARP) Diet and Health Study, a prospective cohort. We identified 2,098 lung cases for EAGLE and 18,533 incident cases in AARP. Diet was assessed by food frequency questionnaire for both studies. Multivariable ORs and HRs and respective 95% confidence intervals (CI) were calculated using unconditional logistic regression and Cox proportional hazards regression for EAGLE and AARP, respectively.Results: Higher frequency of intake of nut consumption was inversely associated with overall lung cancer risk (highest vs. lowest quintile, OREAGLE = 0.74; 95% CI, 0.57-0.95; HRAARP = 0.86; 95% CI, 0.81-0.91), regardless of smoking status. Results from the prospective cohort showed similar associations across histologic subtypes and a more pronounced benefits from nut consumption for those who smoked 1 to 20 cigarettes/day (OREAGLE = 0.61; 95% CI, 0.39-0.95; HRAARP = 0.83; 95% CI, 0.74-0.94).Conclusions: Nut consumption was inversely associated with lung cancer in two large population-based studies, and associations were independent of cigarette smoking and other known risk factors.Impact: To our knowledge, this is the first study that examined the association between nut consumption and lung cancer risk by histologic subtypes and smoking intensity. Cancer Epidemiol Biomarkers Prev; 26(6); 826-36. ©2017 AACR.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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