Does brain creatine content rely on exogenous creatine in healthy youth? A proof-of-principle study
Merege-Filho CA, Otaduy MC, de Sá-Pinto AL, de Oliveira MO, de Souza Gonçalves L, Hayashi AP, Roschel H, Pereira RM, Silva CA, Brucki SM, da Costa Leite C, Gualano B
Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme · 21 citations
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Government
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- University or hospital
- Universidade de São Paulo
Based on 3 listed funder(s).
Publication
- Published
- 2016-10-05 · Appl Physiol Nutr Metab · vol. 42 · issue 2 · pp. 128–134
- Publisher
- NRC Research Press
- Cited
- 42 citations · more than 69% of similar papers · 0.7× the field average
- References
- 39 works
- Access
- Paywalled
- Research areas
- Muscle metabolism and nutrition · Cardiovascular and exercise physiology · Sports Performance and Training
- Keywords
- Creatine, Hippocampus, Prefrontal cortex, Placebo, Medicine, Psychology, Cognition, Creatine Monohydrate, Internal medicine, Magnetic resonance imaging, Neuropsychology, Endocrinology, Neuroscience, Pathology
- MeSH
- brain, hippocampus, prefrontal cortex, occipital lobe, neurons, humans, creatine, double-blind method, cognition, models, neurological, dietary supplements, child, brazil, female, male, child nutritional physiological phenomena, executive function, performance-enhancing substances, functional neuroimaging, proton magnetic resonance spectroscopy
12 authors
From BR
- Carlos Alberto Abujabra Merege-FilhoUniversidade de São Paulo
- Maria Concepción García OtaduyUniversidade de São Paulo
- Ana Lúcia de Sá‐PintoUniversidade de São Paulo
- Maira Okada de OliveiraUniversidade de São Paulo
- Lívia de Souza GonçalvesUniversidade de São Paulo
- Ana Paula HayashiUniversidade de São Paulo
Abstract
It has been hypothesized that dietary creatine could influence cognitive performance by increasing brain creatine in developing individuals. This double-blind, randomized, placebo-controlled, proof-of-principle study aimed to investigate the effects of creatine supplementation on cognitive function and brain creatine content in healthy youth. The sample comprised 67 healthy participants aged 10 to 12 years. The participants were given creatine or placebo supplementation for 7 days. At baseline and after the intervention, participants undertook a battery of cognitive tests. In a random subsample of participants, brain creatine content was also assessed in the regions of left dorsolateral prefrontal cortex, left hippocampus, and occipital lobe by proton magnetic resonance spectroscopy (1H-MRS) technique. The scores obtained from verbal learning and executive functions tests did not significantly differ between groups at baseline or after the intervention (all p > 0.05). Creatine content was not significantly different between groups in left dorsolateral prefrontal cortex, left hippocampus, and occipital lobe (all p > 0.05). In conclusion, a 7-day creatine supplementation protocol did not elicit improvements in brain creatine content or cognitive performance in healthy youth, suggesting that this population mainly relies on brain creatine synthesis rather than exogenous creatine intake to maintain brain creatine homeostasis.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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