Funded in part by Cereal Partners Worldwide
A High Rate of Non-Compliance Confounds the Study of Whole Grains and Weight Maintenance in a Randomised Intervention Trial-The Case for Greater Use of Dietary Biomarkers in Nutrition Intervention Studies
Kristensen M, Pelletier X, Ross AB, Thielecke F
Nutrients · 21 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Intake biomarkers
Who paid for it
- Funding
- Industry funded
- Company
- Cereal Partners Worldwide
Based on 1 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2017-01-11 · Nutrients · vol. 9 · issue 1 · p. 55
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 35 citations · more than 94% of similar papers · 4.1× the field average
- Impact
- Top 10% most cited in its field
- References
- 53 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Nutritional Studies and Diet · Nutrition and Health in Aging · Diet and metabolism studies
- Keywords
- Intervention (counseling), Medicine, Compliance (psychology), Randomized controlled trial, Whole grains, Physical therapy, Environmental health, Internal medicine, Food science, Psychology, Biology
- MeSH
- humans, weight loss, resorcinols, body mass index, diet, reducing, patient compliance, biomedical research, research design, adult, middle aged, patient satisfaction, france, female, overweight, nutritional sciences, secondary prevention, young adult, biomarkers, whole grains, obesity, metabolically benign, body weight maintenance, diet, healthy
4 authors
From DK, CH, SE
- Mette KristensenUniversity of Copenhagen
- Xavier Pelletier
- Alastair B. Ross · correspondingNestlé (Switzerland); Chalmers University of Technology
- Frank ThieleckeCereal Partners Worldwide (Switzerland)
Abstract
Observational studies consistently find an inverse relationship between whole-grain intake and weight gain. We aimed to confirm this in an open-label researcher-blinded parallel design randomised trial. A total of 179 overweight/obese women with a habitually low whole-grain intake (p = 0.052). Plasma alkylresorcinol concentrations, biomarkers of wholegrain wheat and rye intake, indicated poor compliance, particularly in the WG group, where >60% of participants had alkylresorcinol concentrations below 70 nmol/L, a concentration indicating low or no intake of whole-grain wheat. Further, weight regain was lower than expected in both intervention groups, further supporting a lack of compliance to the post-weight-loss diet. The rate of compliance was too low to conclude any effect of whole grain on weight maintenance, and reinforces the need to use objective measures of compliance in nutrition intervention studies.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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