Pharmacokinetic Evaluation of a Single Intramuscular High Dose versus an Oral Long-Term Supplementation of Cholecalciferol
Wylon K, Drozdenko G, Krannich A, Heine G, Dölle S, Worm M
PloS one · 23 citations
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Possibly industry funded
- Government
- Deutsche Forschungsgemeinschaft
- Grants
- Deutsche Forschungsgemeinschaft (SFB 650)
Based on 1 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2017-01-23 · PLoS One · vol. 12 · issue 1 · p. e0169620
- Publisher
- Public Library of Science
- Cited
- 30 citations · more than 85% of similar papers · 1.9× the field average
- References
- 28 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Vitamin D Research Studies · Urticaria and Related Conditions · Blood properties and coagulation
- Keywords
- Cholecalciferol, Vitamin D and neurology, Pharmacokinetics, Medicine, Internal medicine, vitamin D deficiency, Intramuscular injection, Placebo, Vitamin, Endocrinology, Oral administration, Calcifediol, Pathology
- MeSH
- humans, cholecalciferol, vitamin d, administration, oral, injections, intramuscular, cohort studies, adult, female, male
6 authors
From DE
- Katharina Sophie WylonCharité - Universitätsmedizin Berlin
- Gennadiy DrozdenkoCharité - Universitätsmedizin Berlin
- Alexander KrannichCharité - Universitätsmedizin Berlin
- Guido HeineCharité - Universitätsmedizin Berlin
- Sabine Dölle-BierkeCharité - Universitätsmedizin Berlin
- Margitta Worm · correspondingCharité - Universitätsmedizin Berlin
Abstract
Background and objectives
Vitamin D deficiency is frequent during the winter and occurs throughout the year in the elderly or patients suffering from autoimmune diseases. The objective of this study was to evaluate the pharmacokinetic properties of oral supplementation versus a single intramuscular injection of cholecalciferol in healthy individuals.
Research design and methods
Up to 8,000 I.U. oral cholecalciferol was administered daily for 84 days in a 4 week dose-escalation setting to vitamin D deficient individuals. In another cohort, a single intramuscular injection of 100,000 I.U. cholecalciferol was given. In both cohorts, individuals without vitamin D intake served as the comparison group. 25-hydroxyvitamin D (25(OH)D) concentrations were measured in all individuals at defined time points throughout the studies.
Results
The mean 25(OH)D serum concentration increased significantly after oral cholecalciferol intake compared to the control group (day 28: 83.4 nmol/l and 42.5 nmol/l; day 56: 127.4 nmol/l and 37.3 nmol/l; day 84: 159.7 nmol/l and 30.0 nmol/l). In individuals receiving 100,000 I.U. cholecalciferol intramuscular, the mean 25(OH)D serum concentration peaked after 4 weeks measuring 70.9 nmol/l compared to 32.7 nmol/l in the placebo group (p = 0.002). The increase of 25(OH)D serum concentrations after 28 days was comparable between both routes of administration (p = 0.264).
Conclusions
Oral and intramuscular cholecalciferol supplementation effectively increased serum 25(OH)D concentrations.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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