Plasma Creatine Kinetics After Ingestion of Microencapsulated Creatine Monohydrate with Enhanced Stability in Aqueous Solutions
Hone M, Kent RM, Scotto di Palumbo A, Bleiel SB, De Vito G, Egan B
Journal of dietary supplements · 1 citation
How it was studied
- Design
- Randomized controlled trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- Irish Research Council
- Grants
- Irish Research Council (EPSPG201491)
Based on 1 listed funder(s).
Publication
- Published
- 2017-01-25 · J Diet Suppl · vol. 14 · issue 4 · pp. 433–445
- Publisher
- Taylor & Francis
- Cited
- 1 citation · more than 1% of similar papers · 0.0× the field average
- References
- 25 works
- Access
- Paywalled
- Research areas
- Muscle metabolism and nutrition · Diet and metabolism studies · Proteins in Food Systems
- Keywords
- Creatine, Creatine Monohydrate, Ingestion, Chemistry, Maltodextrin, Bioavailability, Aqueous solution, Placebo, Plasma concentration, Animal science, Endocrinology, Internal medicine, Medicine, Food science, Chromatography, Biochemistry, Pharmacology, Biology, Organic chemistry
- MeSH
- humans, creatine, phytosterols, diosgenin, milk proteins, protein hydrolysates, solutions, double-blind method, random allocation, drug compounding, drug stability, biological availability, eating, adult, male, healthy volunteers
6 authors
From IE
- Michelle HoneUniversity College Dublin; Sport Ireland; Dublin City University
- Robert M. KentAnaBio Technologies (Ireland)
- Alessandro Scotto di PalumboUniversity College Dublin; Sport Ireland
- Sinéad B. BleielAnaBio Technologies (Ireland)
- Giuseppe De VitoUniversity College Dublin; Sport Ireland
- Brendan Egan · correspondingUniversity College Dublin; Sport Ireland; Dublin City University
Abstract
Creatine monohydrate represents one of the largest sports supplement markets. Enhancing creatine (CRE) stability in aqueous solutions, such as with microencapsulation, represents innovation potential. Ten physically active male volunteers were randomly assigned in a double-blind design to either placebo (PLA) (3-g maltodextrin; n = 5) or microencapsulated CRE (3-g creatine monohydrate; n = 5) conditions. Experimental conditions involved ingestion of the samples in a 70-mL ready-to-drink format. CRE was delivered in a novel microencapsulation matrix material consisting entirely of hydrolyzed milk protein. Three hours after ingestion, plasma creatine concentrations were unchanged during PLA, and averaged ∼45 μM. During CRE, plasma creatine concentration peaked after 30 min at 101.6 ± 14.9 μM (p < 0.05), representing a 2.3-fold increase over PLA. Thereafter, plasma creatine concentration gradually trended downwards but remained significantly elevated (∼50% above resting levels) 3 hr after ingestion. These results demonstrate that the microencapsulated form of creatine monohydrate reported herein remains bioavailable when delivered in aqueous conditions, and has potential utility in ready-to-drink formulations for creatine supplementation.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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