Withania somnifera Root Extract Enhances Chemotherapy through 'Priming'
Henley AB, Yang L, Chuang KL, Sahuri-Arisoylu M, Wu LH, Bligh SW, Bell JD
PloS one · 13 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- In vitro/mechanistic study (classified by our AI screen)
- Studied in
- Cells or lab samples
- Main outcome
- Mechanisms only
Who paid for it
- Funding
- Independent funding
- Government
- Medical Research Council
Based on 1 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2017-01-27 · PLoS One · vol. 12 · issue 1 · p. e0170917
- Publisher
- Public Library of Science
- Cited
- 23 citations · more than 85% of similar papers · 1.9× the field average
- References
- 48 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Phytochemicals and Medicinal Plants · Medicinal Plants and Neuroprotection · Vitamin C and Antioxidants Research
- Keywords
- Withania somnifera, Priming (agriculture), Reactive oxygen species, Pharmacology, Oxidative stress, Biology, Mitochondrion, Mechanism (biology), Cisplatin, Traditional medicine, Biochemistry, Medicine, Botany, Chemotherapy, Pathology
- MeSH
- ht29 cells, mitochondria, humans, withania, plant roots, colorectal neoplasms, cisplatin, plant extracts, medicine, ayurvedic, oxidative stress
7 authors
From GB, TW, CN
- Aine Brigette HenleyUniversity of Westminster
- Ling YangChina Medical University
- Kun-Lin ChuangChina Medical University
- Meliz Sahuri-ArisoyluUniversity of Westminster
- Lihong WuShanghai University of Traditional Chinese Medicine
- S. W. Annie Bligh · correspondingUniversity of Westminster
Abstract
Withania somnifera extracts are known for their anti-cancerous, anti-inflammatory and antioxidative properties. One of their mechanisms of actions is to modulate mitochondrial function through increasing oxidative stress. Recently 'priming' has been suggested as a potential mechanism for enhancing cancer cell death. In this study we demonstrate that 'priming', in HT-29 colon cells, with W. somnifera root extract increased the potency of the chemotherapeutic agent cisplatin. We have also showed the W. somnifera root extract enhanced mitochondrial dysfunction and that the underlying mechanism of 'priming' was selectively through increased ROS. Moreover, we showed that this effect was not seen in non-cancerous cells.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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