Funded in part by Nutricia Research, Nutricia Advanced Medical Nutrition
Sufficient levels of 25-hydroxyvitamin D and protein intake required to increase muscle mass in sarcopenic older adults - The PROVIDE study
Verlaan S, Maier AB, Bauer JM, Bautmans I, Brandt K, Donini LM, Maggio M, McMurdo MET, Mets T, Seal C, Wijers SLJ, Sieber C, Boirie Y, Cederholm T
Clinical nutrition (Edinburgh, Scotland) · 89 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Industry funded
- Company
- Nutricia Research, Nutricia Advanced Medical Nutrition
Based on 1 listed funder(s).
Publication
- Published
- 2017-01-17 · Clin Nutr · vol. 37 · issue 2 · pp. 551–557
- Publisher
- Elsevier BV
- Cited
- 156 citations · more than 98% of similar papers · 7.5× the field average
- Impact
- Top 10% most cited in its field
- References
- 36 works
- Access
- Open access (hybrid journal) · CC-BY-NC-ND
- Research areas
- Nutrition and Health in Aging · Vitamin D Research Studies · Muscle Physiology and Disorders
- Keywords
- Sarcopenia, Medicine, Anabolism, Vitamin D and neurology, Sarcopenic obesity, Internal medicine, Endocrinology, Body mass index, Nutritional Supplementation, Physiology
- MeSH
- muscle, skeletal, humans, vitamins, vitamin d, leucine, dietary proteins, treatment outcome, geriatric assessment, double-blind method, nutritional status, aged, female, male, muscle strength, sarcopenia, whey proteins
14 authors
From NL, AU, DE, BE, GB, IT, FR, SE
- Sjors Verlaan · correspondingGGD Amsterdam; Nutricia Research (Netherlands); Vrije Universiteit Amsterdam; Amsterdam UMC Location Vrije Universiteit Amsterdam
- Andrea Britta MaierThe Royal Melbourne Hospital; The University of Melbourne; Amsterdam Movement Sciences; Vrije Universiteit Amsterdam
- Jürgen Martin BauerCarl von Ossietzky Universität Oldenburg
- Ivan BautmansVrije Universiteit Brussel
- Kirsten BrandtMRC Elsie Widdowson Laboratory; Newcastle University
- Lorenzo M. DoniniSapienza University of Rome
Abstract
Background
Inadequate nutritional intake and altered response of aging muscles to anabolic stimuli from nutrients contribute to the development of sarcopenia. Nutritional interventions show inconsistent results in sarcopenic older adults, which might be influenced by their basal nutritional status.
Objective
To test if baseline serum 25-hydroxyvitamin D (25(OH)D) concentrations and dietary protein intake influenced changes in muscle mass and function in older adults who received nutritional intervention.
Methods and design
Post-hoc analysis was performed in the PROVIDE study that was a randomized controlled, double blind trial among 380 sarcopenic older adults. This study showed that those who received a vitamin D and leucine-enriched whey protein medical nutrition drink for 13 weeks gained more appendicular muscle mass (aMM), and improved lower-extremity function as assessed by the chair stand test compared with controls. To define low and high groups, a baseline serum concentration of 50 nmol/L 25(OH)D and baseline dietary protein intake of 1.0 g/kg/d were used as cut offs.
Results
At baseline, participants with lower 25(OH)D concentrations showed lower muscle mass, strength and function compared with participants with a high 25(OH)D, while the group with lower protein intake (g/kg/day) had more muscle mass at baseline compared with the participants with higher protein intake. Participants with higher baseline 25(OH)D concentrations and dietary protein intake had, independent of other determinants, greater gain in appendicular muscle mass, skeletal muscle index (aMM/h2), and relative appendicular muscle mass (aMM/body weight × 100%) in response to the nutritional intervention. There was no effect modification of baseline 25(OH)D status or protein intake on change in chair-stand test.
Conclusions
Sufficient baseline levels of 25(OH)D and protein intake may be required to increase muscle mass as a result of intervention with a vitamin D and protein supplement in sarcopenic older adults. This suggests that current cut-offs in the recommendations for vitamin D and protein intake could be considered the "minimum" for adults with sarcopenia to respond adequately to nutrition strategies aimed at attenuating muscle loss.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC-ND).
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