25-Hydroxyvitamin D Status and Risk for Colorectal Cancer and Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Epidemiological Studies
Ekmekcioglu C, Haluza D, Kundi M
International journal of environmental research and public health · 56 citations
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Independent funding
Based on full-text disclosure statement.
Publication
- Published
- 2017-01-28 · Int J Environ Res Public Health · vol. 14 · issue 2 · p. 127
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 84 citations · more than 91% of similar papers · 2.5× the field average
- Impact
- Top 10% most cited in its field
- References
- 115 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Vitamin D Research Studies · Vitamin C and Antioxidants Research · Bone health and osteoporosis research
- Keywords
- Medicine, Epidemiology, Colorectal cancer, Meta-analysis, Internal medicine, Diabetes mellitus, Type 2 Diabetes Mellitus, Oncology, Cancer, Endocrinology
- MeSH
- humans, colorectal neoplasms, diabetes mellitus, type 2, vitamin d deficiency, vitamin d, risk factors, epidemiologic studies, observational studies as topic
3 authors
From AT
- Cem Ekmekçioğlu · correspondingMedical University of Vienna
- Daniela HaluzaMedical University of Vienna
- Michael KundiMedical University of Vienna
Abstract
Epidemiological evidence suggests an association between low vitamin D status and risk for various outcomes including cardiovascular diseases, cancer, and type 2 diabetes mellitus (T2DM). Analyzing serum 25-hydroxyvitamin D [25(OH)D] is the most established means to evaluate an individual's vitamin D status. However, cutoff values for 25(OH)D insufficiency as well as for optimal 25(OH)D levels are controversial. This systematic review critically summarizes the epidemiological evidence regarding 25(OH)D levels and the risk for colorectal cancer and T2DM. The meta-analytical calculation revealed a pooled relative risk (RR) of 0.62 (CI 0.56-0.70; I² = 14.7%) for colorectal cancer and an RR of 0.66 (CI 0.61-0.73; I² = 38.6%) for T2DM when comparing individuals with the highest category of 25(OH)D with those in the lowest. A dose-response analysis showed an inverse association between 25(OH)D levels and RR for both outcomes up to concentrations of about 55 ng/mL for colorectal cancer and about 65 ng/mL for T2DM. At still higher 25(OH)D levels the RR increases slightly, consistent with a U-shaped association. In conclusion, a higher 25(OH)D status is associated with a lower risk for colorectal cancer and T2DM; however, this advantage is gradually lost as levels increase beyond 50-60 ng/mL.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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