Impact of hot and cold exposure on human skeletal muscle gene expression
Zak RB, Shute RJ, Heesch MW, La Salle DT, Bubak MP, Dinan NE, Laursen TL, Slivka DR
Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme · 25 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Mechanisms only
Who paid for it
- Funding
- Independent funding
- Government
- National Institute of General Medical Sciences
- Government
- NIGMS NIH HHS
- Grants
- National Institute of General Medical Sciences (P20GM109090); National Institute of General Medical Sciences (P20 GM103427)
Based on 2 listed funder(s).
Publication
- Published
- 2016-12-01 · Appl Physiol Nutr Metab · vol. 42 · issue 3 · pp. 319–325
- Publisher
- NRC Research Press
- Cited
- 32 citations · more than 79% of similar papers · 1.1× the field average
- References
- 31 works
- Access
- Open access (repository copy)
- Research areas
- Adipose Tissue and Metabolism · Muscle metabolism and nutrition · Muscle Physiology and Disorders
- Keywords
- Skeletal muscle, Mitochondrial biogenesis, Gene expression, Internal medicine, Endocrinology, Myogenesis, Vastus lateralis muscle, Endurance training, Chemistry, VO2 max, Biogenesis, Biology, Mitochondrion, Gene, Medicine, Biochemistry
- MeSH
- muscle, skeletal, mitochondria, humans, rna, messenger, biopsy, body temperature, exercise, gene expression, gene expression regulation, oxygen consumption, muscle development, adult, male, cold temperature, hot temperature, young adult, proteolysis
8 authors
From US
- Roksana ZakUniversity of Nebraska at Omaha
- Robert J. ShuteUniversity of Nebraska at Omaha
- Matthew HeeschUniversity of Nebraska at Omaha
- David Taylor La SalleUniversity of Nebraska at Omaha
- Matthew P. BubakUniversity of Nebraska at Omaha
- Nicholas E. DinanUniversity of Nebraska at Omaha
Abstract
Many human diseases lead to a loss of skeletal muscle metabolic function and mass. Local and environmental temperature can modulate the exercise-stimulated response of several genes involved in mitochondrial biogenesis and skeletal muscle function in a human model. However, the impact of environmental temperature, independent of exercise, has not been addressed in a human model. Thus, the purpose of this study was to compare the effects of exposure to hot, cold, and room temperature conditions on skeletal muscle gene expression related to mitochondrial biogenesis and muscle mass. Recreationally trained male subjects (n = 12) had muscle biopsies taken from the vastus lateralis before and after 3 h of exposure to hot (33 °C), cold (7 °C), or room temperature (20 °C) conditions. Temperature had no effect on most of the genes related to mitochondrial biogenesis, myogenesis, or proteolysis (p > 0.05). Core temperature was significantly higher in hot and cold environments compared with room temperature (37.2 ± 0.1 °C, p = 0.001; 37.1 ± 0.1 °C, p = 0.013; 36.9 ± 0.1 °C, respectively). Whole-body oxygen consumption was also significantly higher in hot and cold compared with room temperature (0.38 ± 0.01 L·min-1, p -1, p -1, respectively). In conclusion, these data show that acute temperature exposure alone does not elicit significant changes in skeletal muscle gene expression. When considered in conjunction with previous research, exercise appears to be a necessary component to observe gene expression alterations between different environmental temperatures in humans.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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