Kodo millet whole grain and bran supplementation prevents high-fat diet induced derangements in a lipid profile, inflammatory status and gut bacteria in mice
Sarma SM, Khare P, Jagtap S, Singh DP, Singh DP, Baboota RK, Podili K, Boparai RK, Kaur J, Bhutani KK, Bishnoi M, Kondepudi KK
Food & function · 26 citations
How it was studied
- Design
- Animal study (classified by our AI screen)
- Studied in
- Animals
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- Department of Biotechnology, Ministry of Science and Technology, India
- Government
- Department of Science and Technology, Ministry of Science and Technology, India
- Government
- Department of Biotechnology , Ministry of Science and Technology
- Government
- Department of Science and Technology, Ministry of Science and Technology
- Grants
- Department of Biotechnology, Ministry of Science and Technology, India (BT/PR6273/FNS/20/622/2012); Department of Science and Technology, Ministry of Science and Technology, India (SB/FT/LS-224/2012)
Based on 4 listed funder(s).
Publication
- Published
- 2017-01-01 · Food Funct · vol. 8 · issue 3 · pp. 1174–1183
- Publisher
- Royal Society of Chemistry
- Cited
- 47 citations · more than 88% of similar papers · 2.4× the field average
- References
- 37 works
- Access
- Paywalled
- Research areas
- Diet and metabolism studies · Food composition and properties · Nutritional Studies and Diet
- Keywords
- Bran, Whole grains, Food science, Obesity, Lipid profile, Bacteria, Gut flora, Biology, Chemistry, Biochemistry, Endocrinology, Cholesterol, Genetics
- MeSH
- animals, mice, inbred c57bl, humans, mice, bacteria, paspalum, obesity, interleukin-6, dietary fiber, dietary supplements, female, male, adipogenesis, lipid metabolism, diet, high-fat, gastrointestinal microbiome, whole grains
11 authors
From RU, IN
- Siddhartha M. SarmaInstitute of Engineering Science; BRIC-National Agri-Food and Biomanufacturing Institute; Panjab University
- Pragyanshu KhareBRIC-National Agri-Food and Biomanufacturing Institute
- Sneha JagtapNational Institute of Pharmaceutical Education and Research
- Dhirendra Pratap SinghBRIC-National Agri-Food and Biomanufacturing Institute
- Ritesh Kumar BabootaBRIC-National Agri-Food and Biomanufacturing Institute
- Koteswaraiah PodiliVellore Institute of Technology University
Abstract
The protective role of kodo millet whole grain and bran supplementation in diet induced obesity has not been investigated. Here we have studied the role of kodo millet supplementation in age matched Swiss albino mice that were randomly divided into groups and fed their respective diets for 16 weeks. A high fat diet increased weight gain, reduced glucose tolerance, increased serum lipids, altered hepatic and adipocyte gene expression and caused dysbiosis in the intestinal beneficial bacteria. Kodo millet supplementation did not affect weight gain but it improved glucose tolerance and prevented an increase in the serum cholesterol and lipid parameters (P ≤ 0.05), modulated adipogenesis related gene expression, decreased serum IL-6 and LPS levels (P ≤ 0.05), promoted selected beneficial gut bacterial abundances (Lactobacillus sp., Bifidobacteria, Akkermansia and Roseburia spp.) and improved the total short chain fatty acid production (P ≤ 0.05) and acetate levels (P ≤ 0.05) in cecal contents. This study provides evidence that kodo millet supplementation alleviates high-fat diet induced changes and hence can be incorporated as a functional ingredient for the management of obesity.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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