Effects of Cholecalciferol vs Calcifediol on Total and Free 25-Hydroxyvitamin D and Parathyroid Hormone
Shieh A, Ma C, Chun RF, Witzel S, Rafison B, Contreras HTM, Wittwer-Schegg J, Swinkels L, Huijs T, Hewison M, Adams JS
The Journal of clinical endocrinology and metabolism · 40 citations
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- National Institute of Arthritis and Musculoskeletal and Skin Diseases
- Government
- National Center for Advancing Translational Sciences
- Government
- NCATS NIH HHS
- Government
- NIAMS NIH HHS
- Grants
- National Center for Advancing Translational Sciences (UL-1TR000124); National Institute of Arthritis and Musculoskeletal and Skin Diseases (R21 AR073018); National Institute of Arthritis and Musculoskeletal and Skin Diseases (P50AR063020); National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR063910)
Based on 4 listed funder(s).
Publication
- Published
- 2017-02-10 · J Clin Endocrinol Metab · vol. 102 · issue 4 · pp. 1133–1140
- Publisher
- Oxford University Press
- Cited
- 58 citations · more than 93% of similar papers · 3.5× the field average
- Impact
- Top 10% most cited in its field
- References
- 45 works
- Access
- Free to read
- Research areas
- Vitamin D Research Studies · Parathyroid Disorders and Treatments · Thyroid Disorders and Treatments
- Keywords
- Cholecalciferol, Calcifediol, Parathyroid hormone, Vitamin D and neurology, Internal medicine, Endocrinology, Medicine, vitamin D deficiency, Calcium
- MeSH
- humans, vitamin d deficiency, calcium, cholecalciferol, calcifediol, parathyroid hormone, vitamin d, adult, middle aged, female, male, young adult
11 authors
From US, CH, NL, GB
- Albert Shieh
- Christina MaUniversity of California, Los Angeles
- Rene F. Chun
- Sten de Boom Witzel
- Brandon Rafison
- Hannah T. M. Contreras
Abstract
Context
Vitamin D deficiency disproportionately affects nonwhite individuals. Controversy persists over how to best restore low 25D levels, and how to best define vitamin D status [total (protein bound plus free) vs free 25D].
Objective
To assess the effects of vitamin D3 (cholecalciferol, or D3) vs 25-hydroxyvitamin D3 (calcifediol, or 25D3) on total and free 25D in a multiethnic cohort of adults, and whether change in parathyroid hormone (PTH) is more strongly associated with total vs free 25D.
Design
Sixteen-week randomized controlled trial. Biochemistries at 0, 4, 8, and 16 weeks.
Setting
Academic medical center.
Participants
Thirty-five adults ≥18 years of age with 25D levels <20 ng/mL.
Intervention
Sixty micrograms (2400 IU)/d of D3 or 20 μg/d of 25D3.
Main outcome measures
Total and free 25D, and PTH.
Results
Baseline total (16.2 ± 3.7 vs 17.0 ± 2.5 ng/mL; P = 0.4) and free (4.2 ± 0.8 vs 4.7 ± 1.0 pg/mL; P = 0.2) 25D were similar between D3 and 25D3 groups, respectively; 25D3 increased total (+25.5 vs +13.8 ng/mL; P = 0.001) and free (+6.6 vs +3.5 pg/mL; P = 0.03) 25D more than D3. By 4 weeks, 87.5% of 25D3 participants had total 25D levels ≥30 ng/mL, compared with 23.1% of D3 participants (P = 0.001). Change in PTH was associated with both total (P = 0.01) and free 25D (P = 0.04).
Conclusions
25D3 increased total and free 25D levels more rapidly than D3, regardless of race/ethnicity. Free and total 25D were similarly associated with change in PTH.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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