Male caffeine and alcohol intake in relation to semen parameters and in vitro fertilization outcomes among fertility patients
Karmon AE, Toth TL, Chiu YH, Gaskins AJ, Tanrikut C, Wright DL, Hauser R, Chavarro JE, Earth Study Team
Andrology · 41 citations
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Independent funding
- University or hospital
- Massachusetts General Hospital
- University or hospital
- Harvard T.H. Chan School of Public Health
- Government
- National Institutes of Health
- University or hospital
- School for Public Health Research
- Government
- National Institute of Diabetes and Digestive and Kidney Diseases
- Government
- National Institute of Environmental Health Sciences
- Government
- Eunice Kennedy Shriver National Institute of Child Health and Human Development
- Government
- NICHD NIH HHS
- Government
- NIDDK NIH HHS
- Government
- NIEHS NIH HHS
- Grants
- National Institute of Environmental Health Sciences (R01ES022955); National Institute of Diabetes and Digestive and Kidney Diseases (P30DK046200); National Institute of Diabetes and Digestive and Kidney Diseases (T-32 DK 007703); Eunice Kennedy Shriver National Institute of Child Health and Human Development (L50 HD056672); National Institute of Environmental Health Sciences (P30-ES-000002); National Institute of Environmental Health Sciences (R01 ES009718); National Institutes of Health (ES 000002); National Institutes of Health (P30 DK046200); National Institutes of Health (ES022955); National Institutes of Health (T32 DK007703‐16); National Institutes of Health (ES009718)
Based on 10 listed funder(s).
Publication
- Published
- 2017-02-10 · Andrology · vol. 5 · issue 2 · pp. 354–361
- Publisher
- Wiley
- Cited
- 62 citations · more than 98% of similar papers · 8.6× the field average
- Impact
- Top 10% most cited in its field
- References
- 33 works
- Access
- Open access (repository copy)
- Research areas
- Reproductive Health and Technologies · Sperm and Testicular Function · Ovarian function and disorders
- Keywords
- Semen quality, Quartile, Fertility, Medicine, Semen, Semen analysis, Assisted reproductive technology, Caffeine, Pregnancy, Live birth, Reproductive medicine, Confounding, In vitro fertilisation, Demography, Physiology, Gynecology, Infertility, Biology, Andrology, Population, Internal medicine, Environmental health, Confidence interval
- MeSH
- humans, infertility, caffeine, sperm count, fertilization in vitro, pregnancy rate, prospective studies, alcohol drinking, sperm motility, fertility, pregnancy, adult, female, male, semen analysis
9 authors
From US
- Anatte Emma Karmon · correspondingHarvard University; Massachusetts General Hospital
- Thomas L. TothHarvard University; Massachusetts General Hospital
- Yu‐Han ChiuHarvard University
- Audrey Jane GaskinsHarvard University
- Cigdem TanrikutHarvard University; Massachusetts General Hospital
- Diane L. WrightHarvard University; Massachusetts General Hospital
Abstract
Much of the literature on the impact of male caffeine and alcohol intake on reproductive outcomes has utilized semen quality as a proxy for male fertility, although semen parameters have a limited predictive value for spontaneous pregnancy. The objective of this study was to investigate whether male caffeine and alcohol intakes are associated with semen parameters and assisted reproductive technology outcome. The Environment and Reproductive Health Study, an ongoing prospective cohort study, enrolls subfertile couples presenting for treatment at an academic fertility center (2007-2012). A total of 171 men with 338 semen analyses and 205 assisted reproductive technology cycles were included in this analysis. Diet was assessed using a 131-item food frequency questionnaire. Mixed models adjusting for potential confounders were used to evaluate the relationships of male caffeine and alcohol intakes with semen parameters and assisted reproductive technology outcomes. There was no association between male caffeine and alcohol intake and semen quality. Male caffeine intake was negatively related to live birth after assisted reproductive technologies (p-trend < 0.01), and male alcohol intake was positively related to live birth after assisted reproductive technologies (p-trend = 0.04). Adjusted live birth rate among couples with a male partner in the highest quartile of caffeine intake (≥272 mg/day) compared to couples with a male partner in the lowest quartile of intake (<99 mg/day) was 19% vs. 55%, respectively, p < 0.01. In terms of alcohol intake, adjusted live birth rate among couples with a male partner in the highest quartile of alcohol intake (≥22 g/day) compared to couples with a male partner in the lowest quartile of intake (<3 g/day) was 61% vs. 28%, respectively, p = 0.05. In conclusion, male pre-treatment caffeine and alcohol intakes were associated with live birth after assisted reproductive technologies, but not with semen parameters, among fertility patients.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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