Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data
Martineau AR, Jolliffe DA, Hooper RL, Greenberg L, Aloia JF, Bergman P, Dubnov-Raz G, Esposito S, Ganmaa D, Ginde AA, Goodall EC, Grant CC, Griffiths CJ, Janssens W, Laaksi I, Manaseki-Holland S, Mauger D, Murdoch DR, Neale R, Rees JR, Simpson S, Stelmach I, Kumar GT, Urashima M, Camargo CA
BMJ (Clinical research ed.) · 1270 citations
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Independent funding
- Government
- National Institute for Health and Care Research
- Government
- Health Technology Assessment Programme
- Government
- National Heart, Lung, and Blood Institute
- Government
- Medical Research Council
- Government
- National Institute for Health Research (NIHR)
- Government
- NHLBI NIH HHS
- Grants
- National Institute for Health and Care Research (RP-PG-0407-10398); National Heart, Lung, and Blood Institute (U10 HL064313); Health Technology Assessment Programme (13/03/25); National Heart, Lung, and Blood Institute (U10 HL098115); National Institute for Health and Care Research (13/03/25); National Institute for Health and Care Research (HTA/13/03/25)
Based on 6 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2017-02-15 · BMJ · vol. 356 · p. i6583
- Cited
- 2088 citations · more than 100% of similar papers · 41.6× the field average
- Impact
- Top 10% most cited in its field
- References
- 61 works
- Access
- Open access (hybrid journal) · CC-BY
- Research areas
- Vitamin D Research Studies · Chronic Obstructive Pulmonary Disease (COPD) Research · Vitamin C and Antioxidants Research
- Keywords
- Medicine, Odds ratio, Placebo, Meta-analysis, Internal medicine, Respiratory tract infections, Confidence interval, Randomized controlled trial, Subgroup analysis, Clinical trial, Vitamin, Incidence (geometry), Respiratory system
- MeSH
- humans, respiratory tract infections, vitamin d, dietary supplements, randomized controlled trials as topic
25 authors
From GB, US, SE, IL, IT, CA, NZ, BE, FI, AU, PL, IN, JP
- Adrian R. Martineau · correspondingQueen Mary University of London; Asthma UK; Blizard Institute
- David A. JolliffeQueen Mary University of London; Blizard Institute
- Richard HooperQueen Mary University of London; Blizard Institute
- Lauren GreenbergQueen Mary University of London; Blizard Institute
- John F. AloiaWinthrop-University Hospital
- Peter BergmanKarolinska Institutet
Abstract
Objectives To assess the overall effect of vitamin D supplementation on risk of acute respiratory tract infection, and to identify factors modifying this effect.Design Systematic review and meta-analysis of individual participant data (IPD) from randomised controlled trials.Data sources Medline, Embase, the Cochrane Central Register of Controlled Trials, Web of Science, ClinicalTrials.gov, and the International Standard Randomised Controlled Trials Number registry from inception to December 2015.Eligibility criteria for study selection Randomised, double blind, placebo controlled trials of supplementation with vitamin D3 or vitamin D2 of any duration were eligible for inclusion if they had been approved by a research ethics committee and if data on incidence of acute respiratory tract infection were collected prospectively and prespecified as an efficacy outcome.Results 25 eligible randomised controlled trials (total 11 321 participants, aged 0 to 95 years) were identified. IPD were obtained for 10 933 (96.6%) participants. Vitamin D supplementation reduced the risk of acute respiratory tract infection among all participants (adjusted odds ratio 0.88, 95% confidence interval 0.81 to 0.96; P for heterogeneity Conclusions Vitamin D supplementation was safe and it protected against acute respiratory tract infection overall. Patients who were very vitamin D deficient and those not receiving bolus doses experienced the most benefit.Systematic review registration PROSPERO CRD42014013953.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
Community trust
Loading…
How much do you trust this study's findings?
Comments
Sign in to rate, comment on or flag this study.Sign inSomething wrong here?
Flag this study if its information, labels or funding look wrong. An editor reviews every flag.
Sign in to rate, comment on or flag this study.Sign inEducational information about published research. Not medical advice, and not a recommendation to start or stop anything.