High Dietary Magnesium Intake is Significantly and Independently Associated with Higher Insulin Sensitivity in a Mexican-Mestizo Population: A Brief Cross-Sectional Report
Moctezuma-Velázquez C, Gómez-Sámano MÁ, Cajas-Sánchez MB, Reyes-Molina DL, Galindo-Guzmán M, Meza-Arana CE, Cuevas-Ramos D, Gómez-Pérez FJ, Gulias-Herrero A
Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion · 6 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cross-sectional study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2017-01-01 · Rev Invest Clin · vol. 69 · issue 1 · pp. 40–46
- Publisher
- Permanyer
- Cited
- 9 citations · more than 69% of similar papers · 0.6× the field average
- References
- 37 works
- Access
- Open access (hybrid journal) · CC-BY-NC-ND
- Research areas
- Magnesium in Health and Disease · Parathyroid Disorders and Treatments · Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- Insulin resistance, Homeostatic model assessment, Medicine, Internal medicine, Endocrinology, Homeostasis, Insulin, Type 2 diabetes, Diabetes mellitus, Magnesium, Magnesium deficiency (plants), Glucose tolerance test, Population, Chemistry, Environmental health
- MeSH
- humans, diabetes mellitus, type 2, insulin resistance, magnesium, insulin, glucose tolerance test, diet, linear models, cross-sectional studies, adult, mexico, female, male, ethnicity
9 authors
From MX, EC
- Carlos Moctezuma‐VelázquezInstituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán
- Miguel Ángel Gómez-SámanoInstituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán
- María Belén Cajas-SánchezUniversidad Católica de Santiago de Guayaquil
- Diana Lorena Reyes-MolinaUniversidad Católica de Santiago de Guayaquil
- Mariana Galindo-GuzmánInstituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán
- Clara-Elena Meza-AranaInstituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán
Abstract
Background
Magnesium acts as a cofactor in many intracellular reactions including phosphorylation of the insulin receptor; therefore, its imbalance can potentially cause insulin resistance. Low serum magnesium concentration has been associated with the development of metabolic syndrome and type 2 diabetes mellitus.
Objective
To study the association between the daily dietary magnesium intake and insulin resistance estimated by the homeostatic model assessment of insulin resistance and homeostatic model assessment 2, as well as insulin sensitivity estimated by the Matsuda index.
Methods
In a university affiliated medical center, 32 participants (22 women, 10 men) that had an indication for testing for type 2 diabetes mellitus with an oral glucose tolerance test were enrolled in this cross-sectional, comparative study. Clinical and biochemical evaluations were carried out including an oral glucose tolerance test. Hepatic insulin resistance index, homeostatic model assessment 2, homeostatic model assessment of insulin resistance, and Matsuda insulin sensitivity were calculated for each participant. They were asked to recall their food ingestion (24 hours) of three days of the past week, including a weekend day; magnesium intake was calculated according to the food nutritional information.
Results
The low dietary magnesium intake group (< 4.5 mg/kg/day) had a higher two-hour insulin concentration after an oral glucose tolerance test compared to those with high dietary magnesium (119.5 [73.0-190.6] vs. 63.5 [25.4-114.2]; p = 0.008), and insulin sensitivity assessed by the Matsuda index was higher in the high dietary magnesium intake group (4.3 ± 3.1 vs. 2.4 ± 1.5; p = 0.042). In multiple linear regression analysis a higher dietary magnesium intake was independently associated (β = 4.93; p = 0.05) with a better insulin sensitivity estimated by the Matsuda index.
Conclusions
Our results suggest that higher magnesium intake is independently associated with better insulin sensitivity in patients at risk for type 2 diabetes mellitus.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC-ND).
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