Supplementation with 2000 IU of Cholecalciferol Is Associated with Improvement of Trabecular Bone Mineral Density and Muscle Power in Pediatric Patients with IBD
Hradsky O, Soucek O, Maratova K, Matyskova J, Copova I, Zarubova K, Bronsky J, Sumnik Z
Inflammatory bowel diseases · 27 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2017-03-07 · Inflamm Bowel Dis · vol. 23 · issue 4 · pp. 514–523
- Publisher
- Oxford University Press
- Cited
- 42 citations · more than 89% of similar papers · 2.6× the field average
- References
- 56 works
- Access
- Paywalled
- Research areas
- Vitamin D Research Studies · Bone health and osteoporosis research · Alkaline Phosphatase Research Studies
- Keywords
- Medicine, Bone mineral, Interquartile range, Cholecalciferol, Vitamin D and neurology, Internal medicine, vitamin D deficiency, Quantitative computed tomography, Bone density, Gastroenterology, Confidence interval, Vitamin, Endocrinology, Osteoporosis
- MeSH
- humans, inflammatory bowel diseases, cholecalciferol, treatment outcome, prospective studies, bone density, dietary supplements, adolescent, child, child, preschool, female, male, bone density conservation agents, muscle strength, young adult, cancellous bone
8 authors
From CZ
- Ondřej HradskýCharles University
- Ondřej Souček · correspondingCharles University
- Klára MaratováCharles University
- Jana MatyskováCharles University
- Ivana ČopováCharles University
- Kristýna ZárubováCharles University
Abstract
Background
Inflammatory bowel diseases (IBD) are associated with altered bone health and increased risk for fractures. Vitamin D deficiency is frequently found in IBD; however, the effect of vitamin D supplementation on bone health of children with IBD is poorly understood. We aimed to observe the changes in volumetric bone density and dynamic muscle functions after vitamin D substitution in a cohort of pediatric patients with IBD.
Methods
This was a prospective observational study of 55 patients (aged 5-19 years) with IBD. Bone quality was assessed using peripheral quantitative computed tomography and muscle functions by jumping mechanography at baseline and after a median of 13.8 (interquartile range, 12.0-16.0) months of daily substitution of 2000 IU of cholecalciferol.
Results
Median serum levels of 25-hydroxyvitamin D increased from 58 nmol/L at the baseline visit to 85 nmol/L at the last follow-up visit (P < 0.001); no signs of overdose were reported. The Z-scores of trabecular bone mineral density, cortical bone cross-sectional area, and maximal muscle power improved significantly during the follow-up period (+0.5, P = 0.001, +0.3, P = 0.002 and +0.5, P = 0.002, respectively). Cholecalciferol substitution was positively associated with trabecular bone mineral density and maximal muscle power (estimates 0.26, 95% confidence interval 0.14-0.37, P < 0.0001 and 0.60, 95% confidence interval 0.32-0.85, P < 0.0001, respectively) but not with the Strength-Strain Index or maximal muscle force (Fmax).
Conclusions
We observed an improvement in bone and muscle parameters after cholecalciferol substitution in pediatric patients with IBD. Therefore, vitamin D substitution can be considered in such patients.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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