Effect of Cruciferous Vegetable Intake on Oxidative Stress Biomarkers: Differences by Breast Cancer Status
Wirth MD, Murphy EA, Hurley TG, Hébert JR
Cancer investigation · 12 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Mechanisms only
- Intake measured by
- Food diaries or recalls
Who paid for it
- Funding
- Independent funding
- Government
- National Cancer Institute
- Government
- National Center for Chronic Disease Prevention and Health Promotion
- Government
- National Center for Complementary and Integrative Health
- Government
- NCCIH NIH HHS
- Government
- NCI NIH HHS
- Government
- NCCDPHP CDC HHS
- Grants
- National Center for Complementary and Integrative Health (K01AT007824); National Cancer Institute ([K05 CA136975); National Center for Chronic Disease Prevention and Health Promotion (U48/DP001936)
Based on 6 listed funder(s).
Publication
- Published
- 2017-03-08 · Cancer Invest · vol. 35 · issue 4 · pp. 277–287
- Publisher
- Taylor & Francis
- Cited
- 15 citations · more than 65% of similar papers · 0.6× the field average
- References
- 68 works
- Access
- Open access (repository copy)
- Research areas
- Genomics, phytochemicals, and oxidative stress · Antioxidant Activity and Oxidative Stress · Glutathione Transferases and Polymorphisms
- Keywords
- Cruciferous vegetables, Breast cancer, Medicine, Oxidative stress, Urine, Urinary system, Morning, Internal medicine, Cancer, Physiology, Endocrinology
- MeSH
- humans, brassica, breast neoplasms, dinoprost, deoxyguanosine, diet, case-control studies, oxidative stress, middle aged, female, biomarkers, tumor, 8-hydroxy-2'-deoxyguanosine
4 authors
From US
- Michael D. Wirth · correspondingUniversity of South Carolina; Connecting Health Innovations (United States)
- E. Angela MurphyUniversity of South Carolina
- Thomas G. HurleyConnecting Health Innovations (United States)
- James R. HébertUniversity of South Carolina; Connecting Health Innovations (United States)
Abstract
This post hoc analysis examined cruciferous vegetable intake on urinary oxidative metabolites in postmenopausal women. Intervention participants (n = 69) received cruciferous vegetables (≥14 cups/week) during a 3-week period. First morning urine measured 8-isoprostane and 8-hydroxy-2'-deoxyguanosine. Dietary intake was estimated using 24-h recalls. When stratified by history of breast cancer, those with breast cancer had significantly lower post-intervention urinary 8-hydroxy-2'-deoxyguanosine values in the intervention arm versus. the control arm (1.1 ng/mL vs. 3.2 ng/mL, p = .01) after adjustment for baseline 8-hydroxy-2'-deoxyguanosine. This was not observed in those without breast cancer. Further work is needed to understand the role of breast cancer in these relationships.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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