CYP1A2 Genotype Variations Do Not Modify the Benefits and Drawbacks of Caffeine during Exercise: A Pilot Study
Salinero JJ, Lara B, Ruiz-Vicente D, Areces F, Puente-Torres C, Gallo-Salazar C, Pascual T, Del Coso J
Nutrients · 56 citations
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
Based on full-text disclosure statement.
Publication
- Published
- 2017-03-11 · Nutrients · vol. 9 · issue 3 · p. 269
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 83 citations · more than 98% of similar papers · 7.6× the field average
- Impact
- Top 10% most cited in its field
- References
- 44 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Coffee research and impacts · Eating Disorders and Behaviors · Muscle metabolism and nutrition
- Keywords
- Caffeine, Ingestion, CYP1A2, Placebo, Genotype, Allele, Polymorphism (computer science), Medicine, Internal medicine, Endocrinology, Pharmacology, Chemistry, Biochemistry, Metabolism, Pathology, Gene
- MeSH
- humans, caffeine, cytochrome p-450 cyp1a2, exercise, pilot projects, double-blind method, anxiety, visual perception, attention, heterozygote, homozygote, polymorphism, single nucleotide, alleles, 5' flanking region, dietary supplements, adult, spain, female, male, young adult, genetic association studies, performance-enhancing substances
8 authors
From ES
- Juan José SalineroCamilo José Cela University
- Beatriz LaraCamilo José Cela University
- Diana Ruiz-VicenteCamilo José Cela University
- Francisco ArecesCamilo José Cela University
- Carlos Puente-TorresCamilo José Cela University
- César Gallo–SalazarCamilo José Cela University
Abstract
Previous investigations have determined that some individuals have minimal or even ergolytic performance effects after caffeine ingestion. The aim of this study was to analyze the influence of the genetic variations of the CYP1A2 gene on the performance enhancement effects of ingesting a moderate dose of caffeine. In a double-blind randomized experimental design, 21 healthy active participants (29.3 ± 7.7 years) ingested 3 mg of caffeine per kg of body mass or a placebo in testing sessions separated by one week. Performance in the 30 s Wingate test, visual attention, and side effects were evaluated. DNA was obtained from whole blood samples and the CYP1A2 polymorphism was analyzed (rs762551). We obtained two groups: AA homozygotes (n = 5) and C-allele carriers (n = 16). Caffeine ingestion increased peak power (682 ± 140 vs. 667 ± 137 W; p = 0.008) and mean power during the Wingate test (527 ± 111 vs. 518 ± 111 W; p p > 0.05). Reaction times were similar between caffeine and placebo conditions (276 ± 31 vs. 269 ± 71 milliseconds; p = 0.681) with no differences between AA homozygotes and C-allele carriers. However, 31.3% of the C-allele carriers reported increased nervousness after caffeine ingestion, while none of the AA homozygotes perceived this side effect. Genetic variations of the CYP1A2 polymorphism did not affect the ergogenic effects and drawbacks derived from the ingestion of a moderate dose of caffeine.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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