Omega-3 Polyunsaturated Fatty Acid (Fish Oil) Supplementation and the Prevention of Clinical Cardiovascular Disease: A Science Advisory From the American Heart Association
Siscovick DS, Barringer TA, Fretts AM, Wu JH, Lichtenstein AH, Costello RB, Kris-Etherton PM, Jacobson TA, Engler MB, Alger HM, Appel LJ, Mozaffarian D, American Heart Association Nutrition Committee of the Council on Lifestyle and Cardiometabolic Health; Council on Epidemiology and Prevention; Council on Cardiovascular Disease in the Young; Council on Cardiovascular and Stroke Nursing; and Council on Clinical Cardiology
Circulation · 443 citations
How it was studied
- Design
- Expert or government fact sheet (classified by our AI screen)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Independent funding
- Government
- National Heart, Lung, and Blood Institute
- Government
- NHLBI NIH HHS
- Grants
- National Heart, Lung, and Blood Institute (R01 HL085710); National Heart, Lung, and Blood Institute (R01 HL101236)
Based on 2 listed funder(s).
Publication
- Published
- 2017-03-13 · Circulation · vol. 135 · issue 15 · pp. e867–e884
- Publisher
- Lippincott Williams & Wilkins
- Cited
- 633 citations · more than 100% of similar papers · 51.8× the field average
- Impact
- Top 10% most cited in its field
- References
- 52 works
- Access
- Free to read
- Research areas
- Fatty Acid Research and Health · Diet and metabolism studies · Diet, Metabolism, and Disease
- Keywords
- Medicine, Eicosapentaenoic acid, Docosahexaenoic acid, Prediabetes, Diabetes mellitus, Polyunsaturated fatty acid, Population, Internal medicine, Clinical trial, Fish oil, Disease, Randomized controlled trial, Intensive care medicine, Type 2 diabetes, Fatty acid, Endocrinology, Environmental health
- MeSH
- humans, cardiovascular diseases, atrial fibrillation, diabetes mellitus, diabetes complications, fatty acids, omega-3, fish oils, cardiac surgical procedures, risk, primary prevention, dietary supplements, heart failure, stroke, secondary prevention
12 authors
From US, DE
- David S. Siscovick
- T. A. BarringerSchrodinger (United States)
- Amanda M. Fretts
- Jason H. Y. Wu
- Alice Hinda LichtensteinAlice-Salomon-Hochschule Berlin
- Rebecca B. Costello
Abstract
Multiple randomized controlled trials (RCTs) have assessed the effects of supplementation with eicosapentaenoic acid plus docosahexaenoic acid (omega-3 polyunsaturated fatty acids, commonly called fish oils) on the occurrence of clinical cardiovascular diseases. Although the effects of supplementation for the primary prevention of clinical cardiovascular events in the general population have not been examined, RCTs have assessed the role of supplementation in secondary prevention among patients with diabetes mellitus and prediabetes, patients at high risk of cardiovascular disease, and those with prevalent coronary heart disease. In this scientific advisory, we take a clinical approach and focus on common indications for omega-3 polyunsaturated fatty acid supplements related to the prevention of clinical cardiovascular events. We limited the scope of our review to large RCTs of supplementation with major clinical cardiovascular disease end points; meta-analyses were considered secondarily. We discuss the features of available RCTs and provide the rationale for our recommendations. We then use existing American Heart Association criteria to assess the strength of the recommendation and the level of evidence. On the basis of our review of the cumulative evidence from RCTs designed to assess the effect of omega-3 polyunsaturated fatty acid supplementation on clinical cardiovascular events, we update prior recommendations for patients with prevalent coronary heart disease, and we offer recommendations, when data are available, for patients with other clinical indications, including patients with diabetes mellitus and prediabetes and those with high risk of cardiovascular disease, stroke, heart failure, and atrial fibrillation.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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