Medium-term effects of dietary nitrate supplementation on systolic and diastolic blood pressure in adults: a systematic review and meta-analysis
Ashor AW, Lara J, Siervo M
Journal of hypertension · 73 citations
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
- Government
- Medical Research Council
- Grants
- Medical Research Council (MR/N007921/1)
Based on 1 listed funder(s).
Publication
- Published
- 2017-03-18 · J Hypertens · vol. 35 · issue 7 · pp. 1353–1359
- Publisher
- Lippincott Williams & Wilkins
- Cited
- 93 citations · more than 97% of similar papers · 6.5× the field average
- Impact
- Top 10% most cited in its field
- References
- 37 works
- Access
- Paywalled
- Research areas
- Nitric Oxide and Endothelin Effects · Sodium Intake and Health · Nutritional Studies and Diet
- Keywords
- Medicine, Confidence interval, Ambulatory, Placebo, Blood pressure, Ambulatory blood pressure, Clinical trial, Internal medicine, Randomized controlled trial, Diastole, Nitrate
- MeSH
- humans, hypertension, nitrates, antihypertensive agents, blood pressure monitoring, ambulatory, blood pressure, dietary supplements, adult
3 authors
From GB
- Ammar Waham AshorNorthumbria University; Newcastle Hospitals - Campus for Ageing and Vitality
- José LaraNorthumbria University
- Mario Siervo · correspondingNewcastle Hospitals - Campus for Ageing and Vitality; Newcastle University
Abstract
Objectives
Dietary nitrate supplementation has been shown to lower blood pressure (BP) particularly in short-term clinical trials. Whether these effects are sustained in the long-term remains to be established. The objective was to conduct a meta-analysis of randomized controlled trials that examined whether dietary nitrate supplementation for more than 1 week has beneficial effects on SBP and DBP.
Methods
Electronic databases were searched from inception until May 2016. Specific inclusion criteria were duration at least 1 week, report of effects on SBP or DBP or both and comparison of inorganic nitrate or beetroot juice supplementation with placebo control groups. Random-effects models were used to calculate the pooled BP effect sizes.
Results
Thirteen trials met eligibility criteria. The trials included a total of 325 participants with seven to 65 participants per study. The duration of each intervention ranged from 1 to 6 weeks. Ten trials assessed BP in resting clinic conditions, whereas 24-h ambulatory and daily home monitorings were used in six and three trials, respectively. Overall, dietary nitrate was associated with a significant decline in SBP [-4.1 mmHg (95% confidence interval: -6.1, -2.2); P < 0.001] and DBP [-2.0 mmHg (95% confidence interval: -3.0, -0.9); P < 0.001]. However, the effect was only significant when measured in resting clinical settings as no significant changes in BP were observed using 24-h ambulatory and daily home BP monitorings.
Conclusion
Positive effects of medium-term dietary nitrate supplementation on BP were only observed in clinical settings, which were not corroborated by more accurate methods such as 24-h ambulatory and daily home monitorings.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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