Dietary cholesterol interacts with SREBF1 to modulate obesity in Chinese children
Zhang S, Lin X, Lynn H, Xu G, Li J, Zhao C, Li M
Molecular nutrition & food research · 6 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cross-sectional study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Food diaries or recalls
Who paid for it
- Funding
- Independent funding
- Government
- Shandong Natural Science Foundation for Young Scholars
Based on 1 listed funder(s).
Publication
- Published
- 2017-03-24 · Mol Nutr Food Res · vol. 61 · issue 9 · p. 1700105
- Publisher
- Wiley
- Cited
- 8 citations · more than 56% of similar papers · 0.2× the field average
- References
- 32 works
- Access
- Paywalled
- Research areas
- Cholesterol and Lipid Metabolism · Regulation of Appetite and Obesity · Peroxisome Proliferator-Activated Receptors
- Keywords
- Cholesterol, Obesity, Single-nucleotide polymorphism, Endocrinology, Internal medicine, Overweight, Biology, Anthropometry, Candidate gene, Medicine, Gene, Genetics, Genotype
- MeSH
- humans, insulin resistance, obesity, cholesterol, dietary, cross-sectional studies, genotype, polymorphism, single nucleotide, child, female, male, sterol regulatory element binding protein 1
7 authors
From CN
- Shixiu Zhang · correspondingShandong University; Fudan University
- Xinying LinShandong University
- Henry Lynn · correspondingFudan University; Shanghai Public Health Clinical Center
- Guifa XuShandong University
- Jun LiShandong University; Shandong Maternal and Child Health Hospital
- Changfeng ZhaoShandong University
Abstract
Scope
Sterol regulatory element binding protein 1 gene (SREBF1) is an important candidate gene for obesity that could be affected by cholesterol. Different SREBF1 gene variants may have distinct responses to cholesterol, leading to different risks for obesity and obesity-related metabolic traits. Thus, we performed a gene-by-diet correlation analysis to test whether SREBF1 gene variation modulate the relationship between cholesterol and obesity.
Methods and results
A total of 642 school-aged children in Jinan, China, were selected by stratified cluster nested sampling. Anthropometric and biochemical measurements, as well as genotyping of tag single nucleotide polymorphisms (SNPs) of SREBF1, were performed in this sample. Nutritional intake assessments were completed using a 24-h dietary recall for three consecutive days. Multilevel mixed-effects linear regression was used to test interactions between SREBF1 SNPs and cholesterol intakes for obesity. Results showed that SREBF1 rs2236513/rs2297508/rs4925119 strongly modulated the relationship between cholesterol intake and serum LDL-cholesterol/total cholesterol levels (p < 0.001). While SREBF1 rs4925118 modulated the relationship between cholesterol intake and homeostasis model assessment of insulin resistance related characteristics (p < 0.05).
Conclusion
These results suggest that cholesterol intake recommendation may need to account for SREBF1 variation.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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