Influence of omega-3 fatty acids on skeletal muscle protein metabolism and mitochondrial bioenergetics in older adults
Lalia AZ, Dasari S, Robinson MM, Abid H, Morse DM, Klaus KA, Lanza IR
Aging · 128 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Controlled clinical trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Mechanisms only
Who paid for it
- Funding
- Independent funding
- University or hospital
- Mayo Clinic
- University or hospital
- Mayo Foundation for Medical Education and Research
- Government
- National Institute of Diabetes and Digestive and Kidney Diseases
- Government
- National Center for Advancing Translational Sciences
- Government
- NIDDK NIH HHS
- Government
- NCATS NIH HHS
- Authors
- At least one author declares a financial tie to industry
- Grants
- National Center for Advancing Translational Sciences (UL1-TR000135); National Institute of Diabetes and Digestive and Kidney Diseases (U24 DK100469); National Center for Advancing Translational Sciences (KL2 TR-000136); National Institute of Diabetes and Digestive and Kidney Diseases (P30-DK084567)
Based on 6 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2017-04-05 · Aging (Albany NY) · vol. 9 · issue 4 · pp. 1096–1129
- Publisher
- Impact Journals LLC
- Cited
- 168 citations · more than 98% of similar papers · 6.9× the field average
- Impact
- Top 10% most cited in its field
- References
- 72 works
- Access
- Open access (hybrid journal) · CC-BY
- Research areas
- Muscle metabolism and nutrition · Nutrition and Health in Aging · Adipose Tissue and Metabolism
- Keywords
- Polyunsaturated fatty acid, Bioenergetics, Sarcopenia, Internal medicine, Anabolism, Endocrinology, Mitochondrion, Oxidative phosphorylation, Respirometry, Respiration, Metabolism, Context (archaeology), Biology, Medicine, Biochemistry, Fatty acid, Anatomy
- MeSH
- muscle, skeletal, sarcoplasmic reticulum, mitochondria, muscle, humans, reactive oxygen species, fatty acids, omega-3, muscle proteins, oxidants, exercise, energy metabolism, oxygen consumption, anaerobic threshold, aging, adolescent, adult, aged, aged, 80 and over, female, male, young adult
7 authors
From US
- Antigoni Z. LaliaMayo Clinic
- Surendra DasariMayo Clinic
- Matthew M. RobinsonMayo Clinic
- Hinnah AbidMayo Clinic
- Dawn M. MorseMayo Clinic
- Katherine A. KlausMayo Clinic
Abstract
Omega-3 polyunsaturated fatty acids (n3-PUFA) are recognized for their anti-inflammatory effects and may be beneficial in the context of sarcopenia. We determined the influence of n3-PUFA on muscle mitochondrial physiology and protein metabolism in older adults. Twelve young (18-35 years) and older (65-85 years) men and women were studied at baseline. Older adults were studied again following n3-PUFA supplementation (3.9g/day, 16 weeks). Muscle biopsies were used to evaluate respiratory capacity (high resolution respirometry) and oxidant emissions (spectrofluorometry) in isolated mitochondria. Maximal respiration was significantly lower in older compared to young. n3-PUFA did not change respiration, but significantly reduced oxidant emissions. Participants performed a single bout of resistance exercise, followed by biopsies at 15 and 18 hours post exercise. Several genes involved in muscle protein turnover were significantly altered in older adults at baseline and following exercise, yet muscle protein synthesis was similar between age groups under both conditions. Following n3-PUFA supplementation, mixed muscle, mitochondrial, and sarcoplasmic protein synthesis rates were increased in older adults before exercise. n3-PUFA increased post-exercise mitochondrial and myofibrillar protein synthesis in older adults. These results demonstrate that n3-PUFA reduce mitochondrial oxidant emissions, increase postabsorptive muscle protein synthesis, and enhance anabolic responses to exercise in older adults.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
Community trust
Loading…
How much do you trust this study's findings?
Comments
Sign in to rate, comment on or flag this study.Sign inSomething wrong here?
Flag this study if its information, labels or funding look wrong. An editor reviews every flag.
Sign in to rate, comment on or flag this study.Sign inEducational information about published research. Not medical advice, and not a recommendation to start or stop anything.