A pilot interventional study to evaluate the impact of cholecalciferol treatment on HbA1c in type 1 diabetes (T1D)
Perchard R, Magee L, Whatmore A, Ivison F, Murray P, Stevens A, Mughal MZ, Ehtisham S, Campbell J, Ainsworth S, Marshall M, Bone M, Doughty I, Clayton PE
Endocrine connections · 10 citations
How it was studied
- Design
- Controlled clinical trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- National Institute for Health and Care Research
- Government
- National Institute for Health Research (NIHR)
- Grants
- National Institute for Health and Care Research (CL-2012-06-005)
Based on 2 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2017-04-05 · Endocr Connect · vol. 6 · issue 4 · pp. 225–231
- Publisher
- Bioscientifica
- Cited
- 20 citations · more than 83% of similar papers · 1.4× the field average
- References
- 39 works
- Access
- Open access (journal) · CC-BY-NC
- Research areas
- Diabetes and associated disorders · Vitamin D Research Studies · Diabetes Management and Research
- Keywords
- Medicine, Cholecalciferol, Vitamin D and neurology, vitamin D deficiency, Internal medicine, Cohort, Vitamin, Diabetes mellitus, Type 2 diabetes, Gastroenterology, Pediatrics, Endocrinology
14 authors
From GB
- Reena PerchardUniversity of Manchester
- Lucia MageeUniversity of Manchester
- Andrew James WhatmoreUniversity of Manchester
- Fiona IvisonManchester University NHS Foundation Trust
- Philip George MurrayUniversity of Manchester; Royal Manchester Children's Hospital
- Adam StevensUniversity of Manchester
Abstract
Background
Higher 25(OH)D3 levels are associated with lower HbA1c, but there are limited UK interventional trials assessing the effect of cholecalciferol on HbA1c.
Aims
(1) To assess the baseline 25(OH)D3 status in a Manchester cohort of children with type 1 diabetes (T1D). (2) To determine the effect of cholecalciferol administration on HbA1c.
Methods
Children with T1D attending routine clinic appointments over three months in late winter/early spring had blood samples taken with consent. Participants with a 25(OH)D3 level 10 years) units. HbA1c levels before and after treatment were recorded.
Results
Vitamin D levels were obtained from 51 children. 35 were Caucasian, 11 South Asian and 5 from other ethnic groups. 42 were vitamin D deficient, but 2 were excluded from the analysis. All South Asian children were vitamin D deficient, with mean 25(OH)D3 of 28 nmol/L. In Caucasians, there was a negative relationship between baseline 25(OH)D3 level and HbA1c (r = -0.484, P t = 1.010, P = 0.328) or at 1 year (t = -1.173, P = 0.248) before and after treatment. One-way ANCOVA, controlling for age, gender, ethnicity, BMI and diabetes duration showed no difference in Δ HbA1c level.
Conclusion
We report important findings at baseline, but in children treated with a stat dose of cholecalciferol, there was no effect on HbA1c. Further studies with larger sample sizes and using maintenance therapy are required.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC).
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