Cholecalciferol 20 000 IU Once Weekly in HIV-Positive Patients with Low Vitamin D Levels: Result from a Cohort Study
Noe S, Heldwein S, Pascucchi R, Oldenbüttel C, Wiese C, von Krosigk A, Jägel-Guedes E, Jäger H, Mayer W, Spinner CD, Wolf E
Journal of the International Association of Providers of AIDS Care · 8 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2017-04-10 · J Int Assoc Provid AIDS Care · vol. 16 · issue 4 · pp. 315–320
- Publisher
- SAGE Publishing
- Cited
- 15 citations · more than 79% of similar papers · 1.4× the field average
- References
- 22 works
- Access
- Open access (journal)
- Research areas
- Vitamin D Research Studies · HIV-related health complications and treatments · Bone health and treatments
- Keywords
- Cholecalciferol, Vitamin D and neurology, Medicine, Internal medicine, Vitamin, vitamin D deficiency, Gastroenterology, Retrospective cohort study, Cohort, Alkaline phosphatase, Endocrinology, Chemistry, Enzyme
- MeSH
- humans, hiv seropositivity, hypocalcemia, vitamin d deficiency, calcium, cholecalciferol, alkaline phosphatase, vitamins, vitamin d, retrospective studies, longitudinal studies, adult, middle aged, female, male
11 authors
From DE
- Sebastian Noé · corresponding
- Silke Heldwein
- Rita Pascucchi
- Celia Oldenbüttel
- Carmen Wiese
- Ariane von Krosigk
Abstract
Purpose
To evaluate efficacy and safety of 20 000 IU cholecalciferol weekly in HIV-infected patients.
Methods
Longitudinal data for 243 HIV-infected patients with paired 25-OH-vitamin D3 values for the same month in 2 consecutive years were stratified by the initiation of supplementation in this retrospective study.
Results
After 1 year of administration of cholecalciferol 20 000 IU weekly, about 78% of patients with initial vitamin D level 20 µg/L and 42% achieved levels >30 µg/L. Supplemented patients with baseline vitamin D levels <20 µg/L showed a significant risk reduction for hypocalcemia ( P = .006; risk difference: 20.8%) and a significantly lower increase in alkaline phosphatase (AP) compared to those in the nonsubstituted group.
Conclusion
The dose of 20 000 IU of cholecalciferol once weekly was found to be safe and effective. Normalization of vitamin D levels within 1 year was observed in 42% to 75% of the patients.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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