Egg Consumption and Incidence of Heart Failure: A Meta-Analysis of Prospective Cohort Studies
Khawaja O, Singh H, Luni F, Kabour A, Ali SS, Taleb M, Ahmed H, Gaziano JM, Djoussé L
Frontiers in nutrition · 25 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Meta-analysis (classified by our AI screen)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Not stated
Who paid for it
- Funding
- Industry funded
- Authors
- At least one author declares a financial tie to industry
Based on full-text disclosure statement.
Publication
- Published
- 2017-03-27 · Front Nutr · vol. 4 · p. 10
- Publisher
- Frontiers Media
- Cited
- 38 citations · more than 70% of similar papers · 1.0× the field average
- References
- 25 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Nutritional Studies and Diet · Sodium Intake and Health · Obesity, Physical Activity, Diet
- Keywords
- Meta-analysis, Funnel plot, Prospective cohort study, Medicine, Confidence interval, Publication bias, Cohort study, Relative risk, Population, Incidence (geometry), Demography, Heart failure, Internal medicine, Environmental health
9 authors
From US
- Owais A. Khawaja · correspondingMercy St. Vincent Medical Center
- Hemindermeet SinghMercy St. Vincent Medical Center
- Faraz Khan LuniMercy St. Vincent Medical Center
- Ameer KabourMercy St. Vincent Medical Center
- Syed Sohail AliMercy St. Vincent Medical Center
- Mohammed TalebMercy St. Vincent Medical Center
Abstract
Introduction
Heart failure (HF) remains a major health problem affecting 5.7 million adults in USA. Data on the association of egg consumption with incident HF have been inconsistent. We, therefore, conducted this meta-analysis of prospective cohort studies to assess the relation of egg consumption with incident HF in the general population.
Methods
Using extensive online search, we conducted a meta-analysis of new onset HF following exposure to egg consumption. A random effects model was used and between studies heterogeneity was estimated with I2. Publication bias was assessed graphically using a funnel plot. All analyses were performed with Comprehensive Meta-Analysis (version 2.2.064).
Results
We identified four prospective cohorts for a total of 105,999 subjects and 5,059 cases of new onset HF. When comparing the highest (≥1/day) to the lowest category of egg consumption, pooled relative risk of HF was 1.25 (95% confidence interval = 1.12-1.39; p = 0.00). There was no evidence for heterogeneity (I2 = 0%) nor publication bias. On sensitivity analysis, stratification by gender differences, follow-up duration, and region where study was conducted did not alter the main conclusion.
Conclusion
Our meta-analysis suggests an elevated risk of incident HF with frequent egg consumption.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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