The serum 25-hydroxyvitamin D levels and hip fracture risk: a meta-analysis of prospective cohort studies
Lv QB, Gao X, Liu X, Shao ZX, Xu QH, Tang L, Chi YL, Wu AM
Oncotarget · 30 citations
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Independent funding
- Government
- National Natural Science Foundation of China
- Government
- Science and Technology Plan Project of Wenzhou, China
- Grants
- National Natural Science Foundation of China (81501933); National Natural Science Foundation of China (Y20160369); National Natural Science Foundation of China (81372014)
Based on 2 listed funder(s).
Publication
- Published
- 2017-03-17 · Oncotarget · vol. 8 · issue 24 · pp. 39849–39858
- Publisher
- Impact Journals LLC
- Cited
- 48 citations · more than 61% of similar papers · 0.8× the field average
- References
- 55 works
- Access
- Open access (free to publish) · CC-BY
- Research areas
- Vitamin D Research Studies · Bone health and osteoporosis research · Vitamin K Research Studies
- Keywords
- Medicine, Hip fracture, Prospective cohort study, Relative risk, Internal medicine, Meta-analysis, Confidence interval, Cohort study, Vitamin D and neurology, Risk factor, Gastroenterology, Osteoporosis
- MeSH
- humans, hip fractures, vitamin d, prevalence, risk factors, prospective studies
8 authors
From CN
- Qingbo LvWenzhou Medical University; Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
- Xiang GaoWenzhou Medical University; Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
- Xiang LiuWenzhou Medical University; Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
- Zhenxuan ShaoWenzhou Medical University; Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
- Qianhui XuWenzhou Medical University; Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
- Li TangWenzhou Medical University; Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
Abstract
Hip fracture has increasingly become a social and economic burden. The relationship between serum 25-hydroxyvitamin D levels and the risk of hip fracture reported by previous studies remains controversial. We searched Pubmed and Embase to identify studies reporting the relationship between serum 25-hydroxyvitamin D levels and risk of hip fracture. Fifteen prospective cohort studies with a total of 51239 participants and 3386 hip fracture cases were included. By pooling the Relative Risk of the lowest vs. the highest categories indicated that lower levels of serum 25-hydroxyvitamin D were more likely to be a risk factor for hip fracture with adjusted Relative Risk (95%Confidence Interval) of 1.58 (1.41, 1.77). Subgroup meta-analysis examining the stability of the primary results achieved the same results. A dose-response meta-analysis showed that the risk of hip fracture was a descending curve below the line of RR=1. The descending trend was obvious when serum 25-hydroxyvitamin D levels were less than 60 nmol/L and was flat when serum 25-hydroxyvitamin D levels were more than 60 nmol/L. We found that individuals with low levels of serum 25-hydroxyvitamin D have an increased risk of hip fracture, and this effect was evident when the serum 25-hydroxyvitamin D levels were less than 60 nmol/L.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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